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Charles Piller

👤 Speaker
1459 total appearances

Appearances Over Time

Podcast Appearances

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

We'll be right back.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

You said you were directed to a lab where you were an undergraduate at University of North Dakota.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And there was someone, I guess, running the lab, right?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Othman Grebe, who became really a mentor of yours, correct?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Yeah, absolutely.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

He taught me an awful lot and became a very good friend.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Turns out that he was one of the people that you blew the whistle on the hardest, yes?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Yeah, I mean, it was a very disappointing end to our relationship.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This, again, is Matthew Schrag.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

He told us earlier about this research with Greeby looking at plaque buildup in the brains of rabbits who'd been fed a high cholesterol diet.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I asked Schrag what his role had been in this research.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So who was it that, in your view, took and manipulated those images before they were published in the paper?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And how much of it had problems?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Meaning manipulated imagery and so on?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So when you called him, ultimately, what was that call like?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I understand that there'd been an earlier misconduct inquiry into his work back in 2006 or 2007.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Do you know anything about that?

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I do now.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Okay, so you were a kid when you worked with him, and now you're an actual academic.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

The 2006 Rabbit paper by Grebe, Schrag and three other co-authors was retracted in 2023.