Chris Masterjohn

is thinking about how do we ramp up mitochondrial energy production?

How do we prevent it from declining and aging so that the brain can rightly perceive that I am in a state of abundance and it is rational to ramp up this metabolic rate?

I think there are – when you have a marker like this, it's not like every single case of high cholesterol represents a failure to convert it into anything good.

Some people just produce more cholesterol or they absorb more cholesterol.

And I don't think those are all equal in terms of their heart disease risk or their health implications.

But sluggish – like high cholesterol is in general a sign of sluggish metabolism under the average set of circumstances.

got left behind in 1976 is Broda Barnes wrote this book called Solved the Riddle of Heart Attacks in 1976.

And his perspective was all about thyroid hormone.

And he argued that people who died of infectious diseases were hypothyroid.

We allowed them to live longer.

Now all the hypothyroid people are getting heart disease.

The reason he thought that is because thyroid hormone communicates to your whole body that you are in a state of abundance.

And so if your brain thinks that you're not and you add thyroid hormone in, now your whole body is receiving the false signal that you are in a state of abundance and you feel better and many things improve and you can argue about whether that's good or bad.

But you're intervening at the point of the communication instead of at the point of actually creating the abundance.

But thyroid hormone does signal take up cholesterol from the cell, move it along, do things with it.

And so no matter whether you're hypothyroid or not, people were up until the 1970s, they were lowering cholesterol and they were lowering heart disease risk by just putting everyone who had high cholesterol on thyroid hormone.

And the reason they stopped doing it is because some practitioners got overzealous and they killed a few people because they overdosed them.

But Broda Barnes argued that, well, we don't have to be overzealous and overdose them.

We can just be rationally dosing thyroid hormone.

I, my perspective is different from Bodo Barnes.