Chuck

your dopamine receptors, because your body's like, wait, wait, wait, this isn't right.

Let me shut this down.

It's not just shutting down the dopamine receptor that makes you want to, you know, do more cocaine or whatever.

It's just shutting your dopamine receptors down.

So you mentioned it earlier, anhedonia, that's...

the idea that you don't receive pleasure from any activity.

And if all of a sudden your dopamine has been shut down such because you've been doing drugs that you're not getting any kind of pleasant, feel-good stimulation from life, then that could be another reason that you up your desire to do drugs.

Yeah.

Yeah, and I think that's – I mean, we talked about it in the addiction app.

It's not just the effect that the drug has on your body, the negative effects that it physiologically has on your body, but the behaviors that you start engaging in when you're under the influence of drugs and want more drugs and maybe can't find the drugs, that's –

Maybe almost worse than the physiological ramifications, you know?

Yeah, and they've also done studies where they found that that risk should or needs to be tied to a reward, like a gain, basically.

There was a study from the University of College in London in 2015 that said subjects whose dopamine levels was higher, it was boosted artificially with medication.

would choose risky options more often if it involved a potential gain.

They didn't see that same thing going on if there was a potential loss involved.

So there's definitely a tie to a gain or another way of saying that would be a reward.

Yes.

Yeah.

All right.

Should we take our final break here?