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César Ramírez Sarmiento

👤 Person
197 total appearances

Appearances Over Time

Podcast Appearances

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

But if you have like a piece that is long enough, then you can fold it.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So proteins also fold upon themselves.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And so they're making these very, very tiny proteins that actually fold upon themselves so they have shape.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And that shape is complementary to different target cells that have proteins that are involved in cellular processes that are related to different diseases that can go from like

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

different allergic reactions to even like treatments for cancer so the idea is to develop like this very very tiny proteins that you can use as a pharmaceutical as a drug and that would be a better solution that developing different chemical compounds that do not offer the same capabilities that these proteins have so i'm really looking forward to see what they do with it

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

Yeah, that's an interesting question.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So I think that I'm seeing a lot of advances right now in making new enzymes.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So enzymes are very difficult to make.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

They have very specific sites on the protein surface.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So if you imagine that you have like a sphere as a protein, then they have like a little hole on the surface that is called the active site.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And the chemical reaction actually happens in that site and that site alone, which means that there has to be

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

very specific amino acids from your protein in very specific positions.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So the methods that we had like a year ago were like pretty bad at the enzyme design.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And so before we will take an enzyme that we know it has some activity for some thing that we wanted to do.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

Like there's a lot of enzymes that do plastic degradation, so we will improve the sequence, but we will never change the structure.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

But nowadays there's a lot of methods that actually can afford that.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And so the idea is that you can create new structures that have never seen before in nature of enzymes, of new enzymes.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And that allows for thinking about new chemical reactions that we can create from scratch.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

So that's very exciting.

TED Talks Daily
The new era of AI-powered protein design | César Ramírez-Sarmiento

And I think that the field is moving forward very fast towards developing these new enzymes for new chemical reactions.