#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
Somebody once said to me, you never want to study longevity in an organism that lives as long as you do.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
If you and I at our age were to start, especially mine, I'm a little older than you, were to start a big study and say, I want to study 20-year-olds.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
and give them different nutrition and see who lives longer.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
And that'll help me figure out for myself what to eat.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
I'll be dead long before the study is in and not be able to benefit from it and also not be able to find the answer.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
And maybe, you know, we want answers before 60 years from now.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
So, those are just a few, and I could go on and on.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
Those are just a few of the many challenges we have in nutrition, and I think we're going to chip away at them, but a lot of it's going to have to be settling for various rough inferences to say,
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
I need to be honest with the public about the limits.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
I need to say, I haven't shown this unequivocally, but it looks like this is the most reasonable answer now or the most supported answer now.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
And I'm willing to accept that, but let's be honest, it's not demonstrated.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
Great example of that, you're seeing the feud in the literature now between Kevin Hall and David Ludwig on the use of crossover designs as an example.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
And crossover designs in which you give person, let's say, diet A followed by diet B, and you give other people a randomized to diet B followed by diet A, they have an Achilles heel.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
that is not there for, let's say, parallel groups where it's just some get diet A and some get diet B. And that is you can have what's called carryover effects.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
And it turns out, I've started to study this, tip my hat to David Ludwig who pointed the issues out to me and I hadn't fully comprehended them before that.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.