Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Pricing

David Feldman

👤 Person
702 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And high HDL and low triglycerides, they're associated with lower cardiovascular disease risk. But as I'm sure you see on social media all the time, they're, again, considered to be secondary, that they're not ultimately going to protect you from sky-high levels of LDL. In identifying this phenotype, I went knocking on the doors of lipidologists and cardiologists and research saying, hey, let's...

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And high HDL and low triglycerides, they're associated with lower cardiovascular disease risk. But as I'm sure you see on social media all the time, they're, again, considered to be secondary, that they're not ultimately going to protect you from sky-high levels of LDL. In identifying this phenotype, I went knocking on the doors of lipidologists and cardiologists and research saying, hey, let's...

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

study this phenotype. To put it quite plainly, most of the interest is in studying populations that are already at severe risk, including having these metabolic problems. Well, I just got done explaining the lipid energy model with regard to why there might be high LDL from heavy successful trafficking of the cargo of fat.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

study this phenotype. To put it quite plainly, most of the interest is in studying populations that are already at severe risk, including having these metabolic problems. Well, I just got done explaining the lipid energy model with regard to why there might be high LDL from heavy successful trafficking of the cargo of fat.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

study this phenotype. To put it quite plainly, most of the interest is in studying populations that are already at severe risk, including having these metabolic problems. Well, I just got done explaining the lipid energy model with regard to why there might be high LDL from heavy successful trafficking of the cargo of fat.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

I would argue that its counterpart, known as atherogenic dyslipidemia, where you have low HDL high triglycerides, is where there's more of a traffic jam. Unfortunately, all of the research is focused there. It's almost impossible to get scientists to be interested in studying, especially prospective studies on folks who are especially healthy but have high levels of LDL and ApoB.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

I would argue that its counterpart, known as atherogenic dyslipidemia, where you have low HDL high triglycerides, is where there's more of a traffic jam. Unfortunately, all of the research is focused there. It's almost impossible to get scientists to be interested in studying, especially prospective studies on folks who are especially healthy but have high levels of LDL and ApoB.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

I would argue that its counterpart, known as atherogenic dyslipidemia, where you have low HDL high triglycerides, is where there's more of a traffic jam. Unfortunately, all of the research is focused there. It's almost impossible to get scientists to be interested in studying, especially prospective studies on folks who are especially healthy but have high levels of LDL and ApoB.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

But that to me is crazy given the fact that you have the variable of interest that we're all focused on right there, perfect for an experiment. So after two years of trying and failing to do this, I said, what the f**k? I'm just going to start my own charity to fundraise for the study that we want to have.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

But that to me is crazy given the fact that you have the variable of interest that we're all focused on right there, perfect for an experiment. So after two years of trying and failing to do this, I said, what the f**k? I'm just going to start my own charity to fundraise for the study that we want to have.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

But that to me is crazy given the fact that you have the variable of interest that we're all focused on right there, perfect for an experiment. So after two years of trying and failing to do this, I said, what the f**k? I'm just going to start my own charity to fundraise for the study that we want to have.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

So the critical question is, are folks who have sky-high levels of LDL and ApoB but are otherwise metabolically healthy, are they going to show that association? Is it going to bear out? The high LDL will associate with a corresponding increase in plaque. I start Citizen Science Foundation in 2019 and I'm raising money after that point, as well as getting together with a protocol team.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

So the critical question is, are folks who have sky-high levels of LDL and ApoB but are otherwise metabolically healthy, are they going to show that association? Is it going to bear out? The high LDL will associate with a corresponding increase in plaque. I start Citizen Science Foundation in 2019 and I'm raising money after that point, as well as getting together with a protocol team.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

So the critical question is, are folks who have sky-high levels of LDL and ApoB but are otherwise metabolically healthy, are they going to show that association? Is it going to bear out? The high LDL will associate with a corresponding increase in plaque. I start Citizen Science Foundation in 2019 and I'm raising money after that point, as well as getting together with a protocol team.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And ultimately we find our principal investigator and Dr. Budoff right here in LA at UCLA at the Lundquist Institute and managed to raise enough money to where we can actually make this study happen. It was, they said that we could do this with 25, 30 people given just how high their LDL cholesterol is. but I wanted a hundred. I knew that was ambitious.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And ultimately we find our principal investigator and Dr. Budoff right here in LA at UCLA at the Lundquist Institute and managed to raise enough money to where we can actually make this study happen. It was, they said that we could do this with 25, 30 people given just how high their LDL cholesterol is. but I wanted a hundred. I knew that was ambitious.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And ultimately we find our principal investigator and Dr. Budoff right here in LA at UCLA at the Lundquist Institute and managed to raise enough money to where we can actually make this study happen. It was, they said that we could do this with 25, 30 people given just how high their LDL cholesterol is. but I wanted a hundred. I knew that was ambitious.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And I basically was telling the community this at the time that was fundraising. I said, you know, I can cut off at any time, but I, I estimate it'll be about $2,000 per lean mass hypersponder participant. So at 50,000, we have enough to go off of, but I, I'd love to get a hundred, but that'd be $200,000 and credit to the low carb community. They stepped up and put that money together.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And I basically was telling the community this at the time that was fundraising. I said, you know, I can cut off at any time, but I, I estimate it'll be about $2,000 per lean mass hypersponder participant. So at 50,000, we have enough to go off of, but I, I'd love to get a hundred, but that'd be $200,000 and credit to the low carb community. They stepped up and put that money together.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

And I basically was telling the community this at the time that was fundraising. I said, you know, I can cut off at any time, but I, I estimate it'll be about $2,000 per lean mass hypersponder participant. So at 50,000, we have enough to go off of, but I, I'd love to get a hundred, but that'd be $200,000 and credit to the low carb community. They stepped up and put that money together.