David Feldman

If you currently believe that the metric of cholesterol is in and of itself the central driver of cardiovascular disease, I often hear terms like atherosclerosis, the development of plaque in the arteries, is a disease of cholesterol, then it's understandable why you may hyper-focus on that as being the central thing to change. And all of your heart disease risk will follow suit.

And that these other risk factors are really ancillary. You know, something like blood pressure and so forth, they all come second to cholesterol.

And that these other risk factors are really ancillary. You know, something like blood pressure and so forth, they all come second to cholesterol.

And that these other risk factors are really ancillary. You know, something like blood pressure and so forth, they all come second to cholesterol.

Well, there's waist to hip ratio. Of course, I'm listing off the things that are in metabolic syndrome. There's high fasting glucose, high A1C, but that gets back to insulin resistance.

Well, there's waist to hip ratio. Of course, I'm listing off the things that are in metabolic syndrome. There's high fasting glucose, high A1C, but that gets back to insulin resistance.

Well, there's waist to hip ratio. Of course, I'm listing off the things that are in metabolic syndrome. There's high fasting glucose, high A1C, but that gets back to insulin resistance.

Honestly, I feel like this shouldn't even be debated anymore. I'm stunned, and I kind of get on a soapbox about this, but I'm stunned that there is so much attention still paid to LDL cholesterol, or for that matter, its major carrier, ApoB, relative to

Honestly, I feel like this shouldn't even be debated anymore. I'm stunned, and I kind of get on a soapbox about this, but I'm stunned that there is so much attention still paid to LDL cholesterol, or for that matter, its major carrier, ApoB, relative to

Honestly, I feel like this shouldn't even be debated anymore. I'm stunned, and I kind of get on a soapbox about this, but I'm stunned that there is so much attention still paid to LDL cholesterol, or for that matter, its major carrier, ApoB, relative to

to insulin resistance syndrome relative to poor metabolic health when without question, poor metabolic health isn't just bad for overall mortality, but specifically to cardiovascular disease. If we're talking about cardiovascular disease risk, That should be one of the first places the conversation starts.

to insulin resistance syndrome relative to poor metabolic health when without question, poor metabolic health isn't just bad for overall mortality, but specifically to cardiovascular disease. If we're talking about cardiovascular disease risk, That should be one of the first places the conversation starts.

to insulin resistance syndrome relative to poor metabolic health when without question, poor metabolic health isn't just bad for overall mortality, but specifically to cardiovascular disease. If we're talking about cardiovascular disease risk, That should be one of the first places the conversation starts.

Because unfortunately, there are a lot of folks, including some challenge cases within my own family, who hear, hey, if you get your LDL cholesterol low enough, you're a low heart disease risk. And the data just does not support that. You have to care about being healthier yourself, particularly when it comes to metabolism.

Because unfortunately, there are a lot of folks, including some challenge cases within my own family, who hear, hey, if you get your LDL cholesterol low enough, you're a low heart disease risk. And the data just does not support that. You have to care about being healthier yourself, particularly when it comes to metabolism.

Because unfortunately, there are a lot of folks, including some challenge cases within my own family, who hear, hey, if you get your LDL cholesterol low enough, you're a low heart disease risk. And the data just does not support that. You have to care about being healthier yourself, particularly when it comes to metabolism.

The study centers around a phenotype I had named in an article in 2017, lean mass hyper responders. So like myself and many others who I was communicating with at the time, we don't just have the high LDL cholesterol. But on top of that, we have the high HDL cholesterol, the low triglycerides. So, of course, high LDL is considered a risk factor independently.

The study centers around a phenotype I had named in an article in 2017, lean mass hyper responders. So like myself and many others who I was communicating with at the time, we don't just have the high LDL cholesterol. But on top of that, we have the high HDL cholesterol, the low triglycerides. So, of course, high LDL is considered a risk factor independently.

The study centers around a phenotype I had named in an article in 2017, lean mass hyper responders. So like myself and many others who I was communicating with at the time, we don't just have the high LDL cholesterol. But on top of that, we have the high HDL cholesterol, the low triglycerides. So, of course, high LDL is considered a risk factor independently.

And high HDL and low triglycerides, they're associated with lower cardiovascular disease risk. But as I'm sure you see on social media all the time, they're, again, considered to be secondary, that they're not ultimately going to protect you from sky-high levels of LDL. In identifying this phenotype, I went knocking on the doors of lipidologists and cardiologists and research saying, hey, let's...