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David Feldman

👤 Person
702 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Because in short, if I have to release more fat and then replete it back again, and I have to power my muscles more with fat and so forth, that metabolism, that pulling the fuel in and out, I have to have... get carried on these ApoB-containing lipoproteins like VLDL, which remodel to LDL when they drop off their fat-based cargo in the form of triglycerides.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Because in short, if I have to release more fat and then replete it back again, and I have to power my muscles more with fat and so forth, that metabolism, that pulling the fuel in and out, I have to have... get carried on these ApoB-containing lipoproteins like VLDL, which remodel to LDL when they drop off their fat-based cargo in the form of triglycerides.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Because in short, if I have to release more fat and then replete it back again, and I have to power my muscles more with fat and so forth, that metabolism, that pulling the fuel in and out, I have to have... get carried on these ApoB-containing lipoproteins like VLDL, which remodel to LDL when they drop off their fat-based cargo in the form of triglycerides.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Almost. This is where it gets tricky because a lot of times when I'm talking about this, folks say, well, wait a sec, the major cargo, the fat that's being carried by lipoproteins is triglycerides. I mentioned that as part of the panel. But a lot of people go on a low-carb diet, and this includes myself, would see their triglyceride levels in the blood test go down. So how can that be?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Almost. This is where it gets tricky because a lot of times when I'm talking about this, folks say, well, wait a sec, the major cargo, the fat that's being carried by lipoproteins is triglycerides. I mentioned that as part of the panel. But a lot of people go on a low-carb diet, and this includes myself, would see their triglyceride levels in the blood test go down. So how can that be?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Almost. This is where it gets tricky because a lot of times when I'm talking about this, folks say, well, wait a sec, the major cargo, the fat that's being carried by lipoproteins is triglycerides. I mentioned that as part of the panel. But a lot of people go on a low-carb diet, and this includes myself, would see their triglyceride levels in the blood test go down. So how can that be?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

If I'm saying you're moving more of these around and you're powered more by fat, well, in truth, the model is positing that there's just more successful delivery. So taking a snapshot of your blood is kind of like taking a snapshot of an active shipping lane that's out there in the ocean, but most of the boats don't have cargo in them. Why?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

If I'm saying you're moving more of these around and you're powered more by fat, well, in truth, the model is positing that there's just more successful delivery. So taking a snapshot of your blood is kind of like taking a snapshot of an active shipping lane that's out there in the ocean, but most of the boats don't have cargo in them. Why?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

If I'm saying you're moving more of these around and you're powered more by fat, well, in truth, the model is positing that there's just more successful delivery. So taking a snapshot of your blood is kind of like taking a snapshot of an active shipping lane that's out there in the ocean, but most of the boats don't have cargo in them. Why?

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Even though you know they're shipping a lot of the cargo because they're successful, they're moving it quickly, and the turnover is faster. So when we're seeing the high cholesterol, what we're doing is we're actually seeing empty boats Boats that started out with a lot of cargo, but are so quickly shipped and taken up by the tissues that are making use of it.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Even though you know they're shipping a lot of the cargo because they're successful, they're moving it quickly, and the turnover is faster. So when we're seeing the high cholesterol, what we're doing is we're actually seeing empty boats Boats that started out with a lot of cargo, but are so quickly shipped and taken up by the tissues that are making use of it.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

Even though you know they're shipping a lot of the cargo because they're successful, they're moving it quickly, and the turnover is faster. So when we're seeing the high cholesterol, what we're doing is we're actually seeing empty boats Boats that started out with a lot of cargo, but are so quickly shipped and taken up by the tissues that are making use of it.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

That gets us all back to this larger theme of metabolism. Because even if you're not on a low-carb diet, having, for example, high HDL cholesterol and low triglycerides tend to be associated with good metabolic health. It's just if you're powered more by carbs, you're shipping less fat. But the turnover of that cargo is still a part of the same story.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

That gets us all back to this larger theme of metabolism. Because even if you're not on a low-carb diet, having, for example, high HDL cholesterol and low triglycerides tend to be associated with good metabolic health. It's just if you're powered more by carbs, you're shipping less fat. But the turnover of that cargo is still a part of the same story.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

That gets us all back to this larger theme of metabolism. Because even if you're not on a low-carb diet, having, for example, high HDL cholesterol and low triglycerides tend to be associated with good metabolic health. It's just if you're powered more by carbs, you're shipping less fat. But the turnover of that cargo is still a part of the same story.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

It's just that if you're somebody like myself or Nick Norwitz or Adrian Sotomoda, You're moving more fat because that's what you're powered by, and therefore you have more empty boats. So in a sense, what I'm saying is the LDL are just a lot of empty boats.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

It's just that if you're somebody like myself or Nick Norwitz or Adrian Sotomoda, You're moving more fat because that's what you're powered by, and therefore you have more empty boats. So in a sense, what I'm saying is the LDL are just a lot of empty boats.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

It's just that if you're somebody like myself or Nick Norwitz or Adrian Sotomoda, You're moving more fat because that's what you're powered by, and therefore you have more empty boats. So in a sense, what I'm saying is the LDL are just a lot of empty boats.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

If you currently believe that the metric of cholesterol is in and of itself the central driver of cardiovascular disease, I often hear terms like atherosclerosis, the development of plaque in the arteries, is a disease of cholesterol, then it's understandable why you may hyper-focus on that as being the central thing to change. And all of your heart disease risk will follow suit.

Dhru Purohit Show
Is Current Thinking Around Cholesterol Outdated? What You Need to Know About Heart Health and The Root Cause of Plaque Build Up with David Feldman

If you currently believe that the metric of cholesterol is in and of itself the central driver of cardiovascular disease, I often hear terms like atherosclerosis, the development of plaque in the arteries, is a disease of cholesterol, then it's understandable why you may hyper-focus on that as being the central thing to change. And all of your heart disease risk will follow suit.