David Friedberg

And so their first indication is to actually inject them into the vitriol fluid in the eyeball, and they'll affect the retina in the eye to address people that have gotten blind from glaucoma or one of these kind of stroke-like diseases that happen in the eye.

And so their first indication is to actually inject them into the vitriol fluid in the eyeball, and they'll affect the retina in the eye to address people that have gotten blind from glaucoma or one of these kind of stroke-like diseases that happen in the eye.

And the expectation with this phase one clinical trial is that the delivery of these Yamanaka factors into the eye

And the expectation with this phase one clinical trial is that the delivery of these Yamanaka factors into the eye

will rejuvenate the retina, make it youthful again, and restore vision.

will rejuvenate the retina, make it youthful again, and restore vision.

If it works, which it's expected to, because we see this result happen in animal models, it could be an extraordinary breakthrough, not just in terms of blindness, but in terms of the first human application of Yamanaka factors to reverse aging.

If it works, which it's expected to, because we see this result happen in animal models, it could be an extraordinary breakthrough, not just in terms of blindness, but in terms of the first human application of Yamanaka factors to reverse aging.

The way they're doing it is they're actually packaging up DNA that will make these proteins into viruses, AAV virus, that is delivered into the eye.

The way they're doing it is they're actually packaging up DNA that will make these proteins into viruses, AAV virus, that is delivered into the eye.

The virus will then go into the retinal cells and then will deliver this payload for this DNA to make these proteins in the eye cells.

The virus will then go into the retinal cells and then will deliver this payload for this DNA to make these proteins in the eye cells.

And it can be turned on and off.

And it can be turned on and off.

Amazingly, they've created a switch mechanism in it

Amazingly, they've created a switch mechanism in it

where the protein production, the production of these Yamanaka factors can be turned on and off by taking an antibiotic called doxycycline.

where the protein production, the production of these Yamanaka factors can be turned on and off by taking an antibiotic called doxycycline.

So the person that gets the delivery of this drug takes the antibiotic, turns on the production of these Yamanaka factors, and then theoretically their eye cells will de-age, will get youthful, and their vision will be restored.

So the person that gets the delivery of this drug takes the antibiotic, turns on the production of these Yamanaka factors, and then theoretically their eye cells will de-age, will get youthful, and their vision will be restored.