David Friedberg

It really, I think, elucidated something pretty scary.

It's off patent now.

And so I'm pretty sure my guess, I haven't looked into this, but my guess is most of this is made generically in China.

And then it's probably packaged up with lots of different brands in the US and all over the world.

So it's one of these chemicals that's just become ubiquitous in our use that just shows up everywhere.

But I think it really speaks to the fact that historically, think about 1995, you can look at what the immediate chemical application of something does to a rat or a human cell.

And you can say like, oh, it didn't cause cancer.

It's good to go.

Let's go.

It didn't cause, quote, toxicity.

Can I ask a question?

Because like if you're- Oh yeah, sorry, that's a great question, Shamad.

So I was gonna talk about this.

Thank you for asking that.

They then took that piclorum exposure and then they looked at all the counties across the United States.

They were able to gather data where there's enough data in California, Connecticut, Georgia, Iowa, New Mexico, Utah, Washington, and they were able to look at piclorum use estimates from the Pesticide National Synthesis Project

and try and deduce in places where piclorum was highly used and not highly used.

And once again, it elucidated signal, which is that when piclorum was used in the environment in the counties more frequently, there was a much higher frequency of colon cancer in those counties.

reasonably strong, the odds ratio is like three x, it's very strong.

Yeah, so I'll put my PCAST hat on.