Dennis McKenna

Like, Wade Davis often says, a story he tells, he said, well, you know, our parents Back in the 60s, they would say, you must never take these things because if you do, you'll never be the same again. That's the fucking point.

Yes, yes. The answer is the data is coming out that, in fact, there are long-term changes in the brain in a beneficial way. So there are short-term changes. There's the trip that you have, you know. And the trip that you have... The therapeutic sort of mechanism behind the benefits of psychedelics, whether psilocybin or LSD or whatever, you've heard of this concept of the default mode network?

Yes, yes. The answer is the data is coming out that, in fact, there are long-term changes in the brain in a beneficial way. So there are short-term changes. There's the trip that you have, you know. And the trip that you have... The therapeutic sort of mechanism behind the benefits of psychedelics, whether psilocybin or LSD or whatever, you've heard of this concept of the default mode network?

Yes, yes. The answer is the data is coming out that, in fact, there are long-term changes in the brain in a beneficial way. So there are short-term changes. There's the trip that you have, you know. And the trip that you have... The therapeutic sort of mechanism behind the benefits of psychedelics, whether psilocybin or LSD or whatever, you've heard of this concept of the default mode network?

Mm-mm. That's a neuroscience term. The default mode network is basically the neural mechanisms that feedback, internal neural feedback mechanisms that maintain what we call ordinary consciousness effectively. Our focus on space and time, our sense of self and being localized. Ordinary consciousness. That's the default mode network.

Mm-mm. That's a neuroscience term. The default mode network is basically the neural mechanisms that feedback, internal neural feedback mechanisms that maintain what we call ordinary consciousness effectively. Our focus on space and time, our sense of self and being localized. Ordinary consciousness. That's the default mode network.

Mm-mm. That's a neuroscience term. The default mode network is basically the neural mechanisms that feedback, internal neural feedback mechanisms that maintain what we call ordinary consciousness effectively. Our focus on space and time, our sense of self and being localized. Ordinary consciousness. That's the default mode network.

Most of the time, the default mode network is where you want to be, you know, because you want to be functional. You want to be able to drive a car and get up and go to work, pay the mortgage, do these things, you know, ordinary functioning. But it can also be a trap and particularly for people with like intractable depression and that sort of thing.

Most of the time, the default mode network is where you want to be, you know, because you want to be functional. You want to be able to drive a car and get up and go to work, pay the mortgage, do these things, you know, ordinary functioning. But it can also be a trap and particularly for people with like intractable depression and that sort of thing.

Most of the time, the default mode network is where you want to be, you know, because you want to be functional. You want to be able to drive a car and get up and go to work, pay the mortgage, do these things, you know, ordinary functioning. But it can also be a trap and particularly for people with like intractable depression and that sort of thing.

Their default mode network in some ways is dysfunctional and they don't, you know, they're in these feedback loops that are harmful, that are not supporting their mental health. So what the psychedelics do is they temporarily disable that default mode network. They effectively let you step out of your reference frame.

Their default mode network in some ways is dysfunctional and they don't, you know, they're in these feedback loops that are harmful, that are not supporting their mental health. So what the psychedelics do is they temporarily disable that default mode network. They effectively let you step out of your reference frame.

Their default mode network in some ways is dysfunctional and they don't, you know, they're in these feedback loops that are harmful, that are not supporting their mental health. So what the psychedelics do is they temporarily disable that default mode network. They effectively let you step out of your reference frame.

It lets you look at your situation from a different perspective. You've stepped out of your reference frame. So if you look at your – Your depression or your trauma, your addiction or various problems that you're facing, you could look at that in a different way. And in that way, you can sort of defuse it. You can sort of overcome that and you can resolve a lot of those things.

It lets you look at your situation from a different perspective. You've stepped out of your reference frame. So if you look at your – Your depression or your trauma, your addiction or various problems that you're facing, you could look at that in a different way. And in that way, you can sort of defuse it. You can sort of overcome that and you can resolve a lot of those things.

It lets you look at your situation from a different perspective. You've stepped out of your reference frame. So if you look at your – Your depression or your trauma, your addiction or various problems that you're facing, you could look at that in a different way. And in that way, you can sort of defuse it. You can sort of overcome that and you can resolve a lot of those things.

So that's the immediate solution. you know therapeutic benefit of something like psilocybin and it may one session may do it or it may take two or three but basically it will resolve it however what they now know is there are persistent changes that last longer than that long after the trip is is over and What we're seeing is – and by we, I mean neuroscientists, not me.

So that's the immediate solution. you know therapeutic benefit of something like psilocybin and it may one session may do it or it may take two or three but basically it will resolve it however what they now know is there are persistent changes that last longer than that long after the trip is is over and What we're seeing is – and by we, I mean neuroscientists, not me.

So that's the immediate solution. you know therapeutic benefit of something like psilocybin and it may one session may do it or it may take two or three but basically it will resolve it however what they now know is there are persistent changes that last longer than that long after the trip is is over and What we're seeing is – and by we, I mean neuroscientists, not me.

So, you know, this is all in the literature. What's happening is there is a change in connectivity of the synapses. in the brain, sort of a re-change that reflects these changes that you're having in the therapeutic state. Connectivity and also the two words are synaptogenesis, forming of connections between neurons. and neurogenesis, which is growth actually of new neurons.