Dhruv Khullar

But it's also the case that we have been trying to do that for decades and not made a lot of progress.

And so in the short term, you know, there are people who could really benefit from these medications today.

And I think we should consider how to get it to as many people as possible who could really benefit from them.

You know, a lot of the health benefits that we've been talking about today, those have been shown in people who are either overweight or struggling with a chronic condition of some sort.

I think what can be concerning is when we're seeing usage that is not supported by evidence and not supported by data.

There's been a lot of growth in, let's say, microdosing or people who just want to lose a couple

pounds or coming on and off the medications.

Those are use cases that don't have data.

We're not sure what the long-term effects are.

We're not sure whether there's any health benefits associated with them.

This has really become kind of a cultural phenomenon where people are using these in all sorts of ways.

As a doctor, I'm looking at the evidence.

I'm seeing kind of where we have the data to support its use.

But of course, people are accessing these medications in all sorts of ways, whether it's direct-to-consumer companies or online or through social media.

And we just don't have the evidence there to support their use.

I think there's going to be more and more options for people on these medications.

And so, you know, right now we have maybe two major types of GLP-1s that people are taking, semaglutide and terzapatide.

There's already another medication that hits not just one receptor or two receptors, but three receptors, ratatoutride, that has completed phase three trials by Eli Lilly.

I think there will be more versions that are oral versions as opposed to injectable versions.

And so I just think there's going to be a lot more activity in this space, whether it's route of administration or trying to mitigate side effects or try to reduce some of the muscle loss that sometimes people experience.