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Dr. Abraham Morgentaler

๐Ÿ‘ค Speaker
944 total appearances

Appearances Over Time

Podcast Appearances

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

Kysotrex is one and the one that I have the most experience with. It's got the easiest dosage. Dosages, by the way, have some weird numbers for the others, but they all work. And, but what's interesting about the orals is that they have the potential to have fewer side effects too. So what's interesting is if I give somebody an injection once a week or every two weeks, levels go up.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

Kysotrex is one and the one that I have the most experience with. It's got the easiest dosage. Dosages, by the way, have some weird numbers for the others, but they all work. And, but what's interesting about the orals is that they have the potential to have fewer side effects too. So what's interesting is if I give somebody an injection once a week or every two weeks, levels go up.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

They usually go above the normal range and then they decline over days to a week or two. With the orals, you have to take them twice a day because the levels go up and stay up only for about six hours or so, four to six hours. They come down. And then you've got to do it again. There's a part of that day where the levels are back to normal.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

They usually go above the normal range and then they decline over days to a week or two. With the orals, you have to take them twice a day because the levels go up and stay up only for about six hours or so, four to six hours. They come down. And then you've got to do it again. There's a part of that day where the levels are back to normal.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

But the guys respond as if their levels are good all day long. So that's very clever. The fact, though, that when we โ€“ the fact that it comes back to normal for part of the day โ€“ It means, though, that the body isn't getting the experience of there being excessive amounts of testosterone.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

But the guys respond as if their levels are good all day long. So that's very clever. The fact, though, that when we โ€“ the fact that it comes back to normal for part of the day โ€“ It means, though, that the body isn't getting the experience of there being excessive amounts of testosterone.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

If I give an injection, one of the side effects of testosterone therapy, we say, is it reduces fertility for men while you're on it. Because the body of the brain, hypothalamus and pituitary have a sensing mechanism, and normally they send chemical signals to the testicle to make testosterone and make sperm.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

If I give an injection, one of the side effects of testosterone therapy, we say, is it reduces fertility for men while you're on it. Because the body of the brain, hypothalamus and pituitary have a sensing mechanism, and normally they send chemical signals to the testicle to make testosterone and make sperm.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

If the sensing mechanism gets the feeling that there's too much testosterone, it stops sending those signals. And so the testicles basically go to sleep. They take a nap. They hibernate. And so sperm counts go down. And some men may notice that their testicles are getting softer, a little smaller.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

If the sensing mechanism gets the feeling that there's too much testosterone, it stops sending those signals. And so the testicles basically go to sleep. They take a nap. They hibernate. And so sperm counts go down. And some men may notice that their testicles are getting softer, a little smaller.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

Most guys, if they're in married relationships or stable relationships, or they're over the age of 45 or 50, they don't care. The single guy who's out there dating might care some. And so there are ways that we can deal with that. But the orals don't seem to suppress those pituitary signals as much. And I think there's a study that's undergoing now looking at sperm counts.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

Most guys, if they're in married relationships or stable relationships, or they're over the age of 45 or 50, they don't care. The single guy who's out there dating might care some. And so there are ways that we can deal with that. But the orals don't seem to suppress those pituitary signals as much. And I think there's a study that's undergoing now looking at sperm counts.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

And I think that that's probably going to be positive. In other words, that the guys will still have sperm. Whereas with injections, usually we get guys down to zero or very close to zero.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

And I think that that's probably going to be positive. In other words, that the guys will still have sperm. Whereas with injections, usually we get guys down to zero or very close to zero.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

I don't think we have enough data yet to say definitively those studies. If they've come out, I haven't seen them yet, but I know that they're underway. And I think that's pretty good. The other thing that we worry about as a risk of testosterone is what's called erythrocytosis. The red blood cell count goes up too high. So here's a fun fact.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

I don't think we have enough data yet to say definitively those studies. If they've come out, I haven't seen them yet, but I know that they're underway. And I think that's pretty good. The other thing that we worry about as a risk of testosterone is what's called erythrocytosis. The red blood cell count goes up too high. So here's a fun fact.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

No, I'm just kidding. No. So here's the thing is that men and women... Lots of controversy around that. Yeah. But just in terms of our regular biology... Most labs will say that the normal red blood cell count, hematocrit, is between, let's say, 38% and 50%. Slightly off depending on the lab, but roughly that. It turns out that there's almost a clean cut between women and men.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

No, I'm just kidding. No. So here's the thing is that men and women... Lots of controversy around that. Yeah. But just in terms of our regular biology... Most labs will say that the normal red blood cell count, hematocrit, is between, let's say, 38% and 50%. Slightly off depending on the lab, but roughly that. It turns out that there's almost a clean cut between women and men.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

And that clean cut happens around 44% or 45%. women tend to be 44 or less, men tend to be 45 and higher. And that difference appears to be related to testosterone. So when I see men who are testosterone deficient, Their hematocrit are often in what I would consider the female range. And some of them actually, if your count is too low, we call that anemia.

The Dr. Gabrielle Lyon Show
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

And that clean cut happens around 44% or 45%. women tend to be 44 or less, men tend to be 45 and higher. And that difference appears to be related to testosterone. So when I see men who are testosterone deficient, Their hematocrit are often in what I would consider the female range. And some of them actually, if your count is too low, we call that anemia.