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Dr. Abud Bakri

πŸ‘€ Speaker
1676 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

Now, is that significant?

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

That seems to be significant.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

But no one's really kind of discussing it, unfortunately.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

Yeah.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

So when it comes to, let's parse out the effects and the different types of compounds that exist in this category.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

So there's the ghrelin side, the ghrelin agonist, like MK-677, not FDA approved, orally available pill that makes you bleed out growth hormone.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

Like you make so much growth hormone in response to that.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

And in non-pulsatile fashion, growth hormone is a very circadian hormone that gets released in the first 90 minutes of slow wave sleep.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

And if you miss that big pulse, you're going to get small pulses throughout the day.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

The question is, is that big pulse better than small little, you know, mini pulses throughout the day?

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

These secretagogues will address the broader category of something called somatopause.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

So you've heard of menopause.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

You've heard of maybe andropause.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

Somatopause is this event that happens somewhere in the 30s where growth hormone production dramatically decreases.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

So if we kind of paint a picture, your pineal gland's aging.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

before puberty, your thymus right after puberty, you know, in your 20s.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

And in your 30s, you're having somatopause.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

That's where your growth hormone production is decreasing.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

You're having, they call it adrenopause, where your adrenals stop making as much DHEA and the different ratio of cortisol.

Huberman Lab
Peptides: The Science, Uses & Safety | Dr. Abud Bakri

And then you're having menopause, andropause, and all the other chronic conditions.