Dr. Adeel Khan
๐ค SpeakerAppearances Over Time
Podcast Appearances
Yeah, that was my take. Until I had the mu cells, that was my take more or less. I would only use the stem cells in very specific situations. But now that's changed because the mu stem cells are actually pluripotent, which means they, and they, new stem cells are very interesting because they act kind of like macrophages.
Yeah, that was my take. Until I had the mu cells, that was my take more or less. I would only use the stem cells in very specific situations. But now that's changed because the mu stem cells are actually pluripotent, which means they, and they, new stem cells are very interesting because they act kind of like macrophages.
They actually eat, they gobble up damaged cells and then they turn into the new tissue. So they'll, for example, in the heart, they'll go to the heart, they'll eat the damaged cardiomyocytes, so like damaged heart cells, and then they'll actually regenerate new cardiomyocytes. So they're actually pluripotent, right? And that's the key difference because they're not just reducing inflammation.
They actually eat, they gobble up damaged cells and then they turn into the new tissue. So they'll, for example, in the heart, they'll go to the heart, they'll eat the damaged cardiomyocytes, so like damaged heart cells, and then they'll actually regenerate new cardiomyocytes. So they're actually pluripotent, right? And that's the key difference because they're not just reducing inflammation.
And that's why new stem cells are, of course, more powerful than these exosomes because they're actually going to regenerate new tissue versus just reducing inflammation
And that's why new stem cells are, of course, more powerful than these exosomes because they're actually going to regenerate new tissue versus just reducing inflammation
which is what the old generation stem cells used to do and that's why when i was using the old generation stem cells i was kind of just using exosomes for the most part because i didn't see the point because i'm like you're just really reducing inflammation but now that we have something that's pluripotent if i'm injecting it for something degenerative and i actually want to regenerate something new then i'm going to use the stem cells so for example with advanced osteoarthritis
which is what the old generation stem cells used to do and that's why when i was using the old generation stem cells i was kind of just using exosomes for the most part because i didn't see the point because i'm like you're just really reducing inflammation but now that we have something that's pluripotent if i'm injecting it for something degenerative and i actually want to regenerate something new then i'm going to use the stem cells so for example with advanced osteoarthritis
If we want to actually stimulate cartilage regeneration, using the new stem cells makes a lot more sense. But if you just want to reduce inflammation, then you can just use the exosome.
If we want to actually stimulate cartilage regeneration, using the new stem cells makes a lot more sense. But if you just want to reduce inflammation, then you can just use the exosome.
Yeah, and there's studies out there showing that the exosomes can create a favorable microenvironment for stem cell differentiation and for stem cells to do their job, basically. So that's why I tend to just combine them because the exosomes are only there for like minutes to hours, you know, like we said, like they're cleared up pretty quickly.
Yeah, and there's studies out there showing that the exosomes can create a favorable microenvironment for stem cell differentiation and for stem cells to do their job, basically. So that's why I tend to just combine them because the exosomes are only there for like minutes to hours, you know, like we said, like they're cleared up pretty quickly.
But then what they do is they go in there, they reduce inflammation, they make it a better microenvironment so that the stem cells can do their job more effectively.
But then what they do is they go in there, they reduce inflammation, they make it a better microenvironment so that the stem cells can do their job more effectively.
So the results since the new stuff has been honestly incredible. And as a physician, you always want your patients to get better. And now we have much more consistent results. With the older stuff, the results were a bit more inconsistent, meaning some people would get better, some people wouldn't. Whereas this stuff just tends to be reproducible.
So the results since the new stuff has been honestly incredible. And as a physician, you always want your patients to get better. And now we have much more consistent results. With the older stuff, the results were a bit more inconsistent, meaning some people would get better, some people wouldn't. Whereas this stuff just tends to be reproducible.
And the way we do it is it's still very specialized, right? And this is the problem too. There's so many stem cell clinics that they don't know how to inject properly. You have to have a very high skill level You can't just, yes, there is a certain homing mechanism, but at the end of the day, the treatments are going to work better if you get them to where they need to go.
And the way we do it is it's still very specialized, right? And this is the problem too. There's so many stem cell clinics that they don't know how to inject properly. You have to have a very high skill level You can't just, yes, there is a certain homing mechanism, but at the end of the day, the treatments are going to work better if you get them to where they need to go.
So for example, if you have a rotator cuff in your shoulder and you don't get the right spot, your results aren't going to be as good as getting it right in the right spot. So, and that takes a skilled, that takes a very skilled, you know, how it's skilled. It'd be very skilled at ultrasound and you have to have a high level of proficiency to be able to do that image guided injection.
So for example, if you have a rotator cuff in your shoulder and you don't get the right spot, your results aren't going to be as good as getting it right in the right spot. So, and that takes a skilled, that takes a very skilled, you know, how it's skilled. It'd be very skilled at ultrasound and you have to have a high level of proficiency to be able to do that image guided injection.