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Dr. Andy Galpin

๐Ÿ‘ค Speaker
9972 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Maybe there's evidence there, but it's from case studies or case control studies. Maybe it's mechanism only or some other model that's close. Maybe research from aging or dementia. Not the same as brain injury, but it shares some mechanisms. You get the idea here. So for example, the SOE for creatine monohydrate is a two. My opinion personally, that's pretty good.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Maybe there's evidence there, but it's from case studies or case control studies. Maybe it's mechanism only or some other model that's close. Maybe research from aging or dementia. Not the same as brain injury, but it shares some mechanisms. You get the idea here. So for example, the SOE for creatine monohydrate is a two. My opinion personally, that's pretty good.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Summarizing the collective evidence here, there's been a lot of research on everything from kids to rugby players to mountain bikers. And collectively, you're going to see it supports cognitive health. It's been shown actually in psychiatric disorders.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Summarizing the collective evidence here, there's been a lot of research on everything from kids to rugby players to mountain bikers. And collectively, you're going to see it supports cognitive health. It's been shown actually in psychiatric disorders.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's, I believe, two randomized control trials that I'm aware of that have found five grams of creatine per day added in addition to antidepressant treatments improve depressive symptoms. So take that for what you will. Regarding TBIs and brain injuries, there's an argument we can make here for preventative use, specifically for neuronal damage and injury.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's, I believe, two randomized control trials that I'm aware of that have found five grams of creatine per day added in addition to antidepressant treatments improve depressive symptoms. So take that for what you will. Regarding TBIs and brain injuries, there's an argument we can make here for preventative use, specifically for neuronal damage and injury.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's been shown to reduce cortical damage following a TBI by anywhere between 35% to 50%. That'd be 5-0. Pretty substantial amount there. Should catch your attention. They don't know exactly how it works, but it's thought to prevent some of that mitochondrial dysfunction I was talking about a few minutes ago. Helps maintain the membrane health.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's been shown to reduce cortical damage following a TBI by anywhere between 35% to 50%. That'd be 5-0. Pretty substantial amount there. Should catch your attention. They don't know exactly how it works, but it's thought to prevent some of that mitochondrial dysfunction I was talking about a few minutes ago. Helps maintain the membrane health.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Certainly has a role in fending off that downstream reactive oxygen species, ATP, calcium. So a lot of those things we just got done covering. That's why we covered them. Creatine probably has a role, again, we need more information here, but likely has a role in either eliminating or at least drastically reducing some of those issues.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Certainly has a role in fending off that downstream reactive oxygen species, ATP, calcium. So a lot of those things we just got done covering. That's why we covered them. Creatine probably has a role, again, we need more information here, but likely has a role in either eliminating or at least drastically reducing some of those issues.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And finally then, what you care more about is the downstream TBI effects have also been documented. What I mean here is sleep, cognition, and actual mood seem to be enhanced with the creatine. Furthermore, there's actually some studies that have specifically been done on kids. There's one I'm thinking of, In detail here, that was everything from 1 to 18 year olds that had severe TBIs.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And finally then, what you care more about is the downstream TBI effects have also been documented. What I mean here is sleep, cognition, and actual mood seem to be enhanced with the creatine. Furthermore, there's actually some studies that have specifically been done on kids. There's one I'm thinking of, In detail here, that was everything from 1 to 18 year olds that had severe TBIs.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In this particular paper, they gave them 0.4 grams per kilogram of body weight. If you do the math there, that ends up being a pretty standard dose, but appropriately it was done based on body size. You have two year olds and 18 year olds, so we can't give them all just five grams. So a relative dose was given to them within four hours post-injury and done so for six months.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In this particular paper, they gave them 0.4 grams per kilogram of body weight. If you do the math there, that ends up being a pretty standard dose, but appropriately it was done based on body size. You have two year olds and 18 year olds, so we can't give them all just five grams. So a relative dose was given to them within four hours post-injury and done so for six months.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In that particular study, they found improvements in everything from amnesia to the length of stay in the ICU, improvements in communication, locomotion, and social skills. And more importantly, one of the things I loved most about this was the researchers were clear in the fact that the treatment provided costs significantly less than the standard treatment protocol.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In that particular study, they found improvements in everything from amnesia to the length of stay in the ICU, improvements in communication, locomotion, and social skills. And more importantly, one of the things I loved most about this was the researchers were clear in the fact that the treatment provided costs significantly less than the standard treatment protocol.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And this is something I felt was really important because I know supplements are not cheap and many of you can't afford any cost whatsoever. But if you can, while creatine, I know, I know I hear this all the time, has gotten more expensive in recent years, it's still likely far cheaper than a standard hospital protocol. So if you can possibly afford it, seems to be a pretty good option.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And this is something I felt was really important because I know supplements are not cheap and many of you can't afford any cost whatsoever. But if you can, while creatine, I know, I know I hear this all the time, has gotten more expensive in recent years, it's still likely far cheaper than a standard hospital protocol. So if you can possibly afford it, seems to be a pretty good option.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Another thing I want to point out here, because it comes up all the time as well, in this study, again, remember, kids, six months of creatine, there were no signs of any kidney, liver, or heart side effects. So overall, we would deem creatine as a pretty strong chance of success in both the physiology as well as actual symptoms with a very low likelihood of injury or adverse effects.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Another thing I want to point out here, because it comes up all the time as well, in this study, again, remember, kids, six months of creatine, there were no signs of any kidney, liver, or heart side effects. So overall, we would deem creatine as a pretty strong chance of success in both the physiology as well as actual symptoms with a very low likelihood of injury or adverse effects.