Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Blog Pricing

Dr. Andy Galpin

๐Ÿ‘ค Speaker
10279 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

But the length is very, very short.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

Now you're talking about something like 0.1 centimeters in length.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

And the reason we want that, or the reason that actually is happening, is because the fibers themselves are what are called single nucleated.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

And so this differs significantly from skeletal muscle that has thousands of nuclei in the cell.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

The nuclei, as a quick reminder, are the place in which you hold your DNA.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

It is the control center of the cell.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

It determines how the cell responds to external stimuli, recovers, repairs.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

It goes through protein synthesis or adds more mitochondria, deletes them, or whatever the case may be.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

This is being run by the nuclei.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

And so by having more of them in the skeletal muscle, it allows it to be extremely plastic and adaptable and responsive to exercise or interventions or lack of exercise or anything else going on.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

I don't need that.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

and cardiac tissue.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

In fact, I don't need it to be growing and shrinking and dying really quickly.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

What I need it to be doing is extremely consistent with both its activation, so its contraction, and the force applied in that contraction.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

So the fact you've got a single nuclei in the cardiac tissue tells you its primary role is not actually adaptation.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

In fact, depending on the study you look at, you're going to see that the muscle fibers in your heart

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

are gonna turn over somewhere between 50 to maybe up to 70% throughout your lifetime.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

Meaning many of the fibers in your heart that you have as a child, especially past puberty, are gonna be there the rest of your life.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

There isn't a huge turnover.

Huberman Lab
Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

Now, that differs considerably if you look at something like the skin.