Dr. Aseem Malhotra
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Podcast Appearances
And they, they've been living in absolute fear of death for months. And some of them break down in tears when I just say to them, listen, I've just done a cardiovascular risk here. Your LDL cholesterol is so-called high, but it's not an issue and you're fine. And your risk is only 2%. And you can just see a sigh of relief and say, doctor, thank God I've been going on thinking that I'm
And they, they've been living in absolute fear of death for months. And some of them break down in tears when I just say to them, listen, I've just done a cardiovascular risk here. Your LDL cholesterol is so-called high, but it's not an issue and you're fine. And your risk is only 2%. And you can just see a sigh of relief and say, doctor, thank God I've been going on thinking that I'm
Then that's, again, misuse, not good use of maybe numbers or statistics. I've been going around thinking that I've got, in the next five years, there's an 80% chance I'm going to die of a heart attack. I'm like, no, it's 2% in 10 years, right? So there's also that as well. So I do think we need to think a little bit carefully on it.
Then that's, again, misuse, not good use of maybe numbers or statistics. I've been going around thinking that I've got, in the next five years, there's an 80% chance I'm going to die of a heart attack. I'm like, no, it's 2% in 10 years, right? So there's also that as well. So I do think we need to think a little bit carefully on it.
Then that's, again, misuse, not good use of maybe numbers or statistics. I've been going around thinking that I've got, in the next five years, there's an 80% chance I'm going to die of a heart attack. I'm like, no, it's 2% in 10 years, right? So there's also that as well. So I do think we need to think a little bit carefully on it.
But coming back to FH, FH affects familial hyperlipidemia, genetically very high cholesterol, okay? 50% of men and 70% of women, right, with FH, untreated, big numbers, will not develop premature heart disease. But 30% of women will, and 50%, which is a lot, will get, even before maybe 50 or 60, will get heart disease.
But coming back to FH, FH affects familial hyperlipidemia, genetically very high cholesterol, okay? 50% of men and 70% of women, right, with FH, untreated, big numbers, will not develop premature heart disease. But 30% of women will, and 50%, which is a lot, will get, even before maybe 50 or 60, will get heart disease.
But coming back to FH, FH affects familial hyperlipidemia, genetically very high cholesterol, okay? 50% of men and 70% of women, right, with FH, untreated, big numbers, will not develop premature heart disease. But 30% of women will, and 50%, which is a lot, will get, even before maybe 50 or 60, will get heart disease.
So I did actually a review paper with a number of international scientists as well, and we published it in BMDA Evidence-Based Medicine. And we thought, okay, That's interesting. 50% of men with FH, familial hyperlipidemia, very high LDL, don't get heart disease and 50% do. Is there anything we can find that's different between them that highlights the subgroup?
So I did actually a review paper with a number of international scientists as well, and we published it in BMDA Evidence-Based Medicine. And we thought, okay, That's interesting. 50% of men with FH, familial hyperlipidemia, very high LDL, don't get heart disease and 50% do. Is there anything we can find that's different between them that highlights the subgroup?
So I did actually a review paper with a number of international scientists as well, and we published it in BMDA Evidence-Based Medicine. And we thought, okay, That's interesting. 50% of men with FH, familial hyperlipidemia, very high LDL, don't get heart disease and 50% do. Is there anything we can find that's different between them that highlights the subgroup?
Like what is the difference between them? First thing, was it the LDL? Is the LDL higher in those ones that get heart disease versus the ones that don't? No difference at all. Ah, that's interesting. It can't be the LDL then. What is it? Well, we found, and Mark, you're going to like this, one of the lipoprotein little a was higher than the one that developed the heart disease.
Like what is the difference between them? First thing, was it the LDL? Is the LDL higher in those ones that get heart disease versus the ones that don't? No difference at all. Ah, that's interesting. It can't be the LDL then. What is it? Well, we found, and Mark, you're going to like this, one of the lipoprotein little a was higher than the one that developed the heart disease.
Like what is the difference between them? First thing, was it the LDL? Is the LDL higher in those ones that get heart disease versus the ones that don't? No difference at all. Ah, that's interesting. It can't be the LDL then. What is it? Well, we found, and Mark, you're going to like this, one of the lipoprotein little a was higher than the one that developed the heart disease.
So FH, you should look at lipoprotein little a, definitely. That gives them a high risk. But what's most promising and interesting is when you correct for insulin resistance...
So FH, you should look at lipoprotein little a, definitely. That gives them a high risk. But what's most promising and interesting is when you correct for insulin resistance...
So FH, you should look at lipoprotein little a, definitely. That gives them a high risk. But what's most promising and interesting is when you correct for insulin resistance...
Right? Their level of risk of heart disease for FH patients almost comes back to someone who's completely healthy. It's only slightly higher. So what were the two markers? Normal waist circumference and low insulin. Yeah. Now, how do you get there? Diet, right? Cutting out the sugar, processed foods, refined carbs. That's right. And it rapidly... So this is amazing.
Right? Their level of risk of heart disease for FH patients almost comes back to someone who's completely healthy. It's only slightly higher. So what were the two markers? Normal waist circumference and low insulin. Yeah. Now, how do you get there? Diet, right? Cutting out the sugar, processed foods, refined carbs. That's right. And it rapidly... So this is amazing.
Right? Their level of risk of heart disease for FH patients almost comes back to someone who's completely healthy. It's only slightly higher. So what were the two markers? Normal waist circumference and low insulin. Yeah. Now, how do you get there? Diet, right? Cutting out the sugar, processed foods, refined carbs. That's right. And it rapidly... So this is amazing.