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Dr. Craig Koniver

👤 Person
906 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

So we do get some day to day variation or topically or under the tongue or something. Peptide, same thing. I don't want to manipulate the hormones, right? I want to just stick within kind of the highways of the lane, swim lanes for how they should operate and then take advantage of that.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And that's been a safe way to do it as opposed to and I've seen it, you know, talking about another peptide, which is Ipermorelin, a growth hormone releasing peptide. Ipramirelin, you inject under the skin, travels up to the pituitary, the posterior pituitary in the brain, which is responsible for putting out growth hormone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And that's been a safe way to do it as opposed to and I've seen it, you know, talking about another peptide, which is Ipermorelin, a growth hormone releasing peptide. Ipramirelin, you inject under the skin, travels up to the pituitary, the posterior pituitary in the brain, which is responsible for putting out growth hormone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And that's been a safe way to do it as opposed to and I've seen it, you know, talking about another peptide, which is Ipermorelin, a growth hormone releasing peptide. Ipramirelin, you inject under the skin, travels up to the pituitary, the posterior pituitary in the brain, which is responsible for putting out growth hormone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

That growth hormone then leaves the pituitary, enters the bloodstream, travels to the liver, where we make insulin-like growth factor one, which then enters the circulation, is very anabolic, meaning growth, healing, mending. You know, as we get older, we make less growth hormone. As we get older, we wear down. Obviously, we get, you know, degenerative conditions.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

That growth hormone then leaves the pituitary, enters the bloodstream, travels to the liver, where we make insulin-like growth factor one, which then enters the circulation, is very anabolic, meaning growth, healing, mending. You know, as we get older, we make less growth hormone. As we get older, we wear down. Obviously, we get, you know, degenerative conditions.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

That growth hormone then leaves the pituitary, enters the bloodstream, travels to the liver, where we make insulin-like growth factor one, which then enters the circulation, is very anabolic, meaning growth, healing, mending. You know, as we get older, we make less growth hormone. As we get older, we wear down. Obviously, we get, you know, degenerative conditions.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Part of that, I don't know what part, for everyone it's a little bit different, is because of our hormonal decline. And so when you can give something like ipamorelin, and we can talk about others, you're actually helping not only push out a little bit of growth hormone for people. We are directing when you push it out, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Part of that, I don't know what part, for everyone it's a little bit different, is because of our hormonal decline. And so when you can give something like ipamorelin, and we can talk about others, you're actually helping not only push out a little bit of growth hormone for people. We are directing when you push it out, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Part of that, I don't know what part, for everyone it's a little bit different, is because of our hormonal decline. And so when you can give something like ipamorelin, and we can talk about others, you're actually helping not only push out a little bit of growth hormone for people. We are directing when you push it out, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

We think that's why it's important for people to be asleep by 10 p.m., between 10 p.m. and 2 a.m., because we think that's the largest pulse of growth hormone during the 24 hour period. Is that right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

We think that's why it's important for people to be asleep by 10 p.m., between 10 p.m. and 2 a.m., because we think that's the largest pulse of growth hormone during the 24 hour period. Is that right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

We think that's why it's important for people to be asleep by 10 p.m., between 10 p.m. and 2 a.m., because we think that's the largest pulse of growth hormone during the 24 hour period. Is that right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah. I mean, that's how I learned it. I agree with you. It feels true to me as well. But taking advantage then of, you know, injecting something like ipramirelin at bedtime, then you're going to, you know, within a few minutes. And with ipramirelin, it's interesting because people will get a little flushing, tingling at times.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah. I mean, that's how I learned it. I agree with you. It feels true to me as well. But taking advantage then of, you know, injecting something like ipramirelin at bedtime, then you're going to, you know, within a few minutes. And with ipramirelin, it's interesting because people will get a little flushing, tingling at times.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Yeah. I mean, that's how I learned it. I agree with you. It feels true to me as well. But taking advantage then of, you know, injecting something like ipramirelin at bedtime, then you're going to, you know, within a few minutes. And with ipramirelin, it's interesting because people will get a little flushing, tingling at times.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what I've seen with the point I'm making is there are some physicians and some pharmacies which, you know, the dosage of ipramone and most of these growth hormone-releasing peptides should be 100 micrograms. That's the max dose to bind the receptor. And, you know, what I've seen is with ipramone, rare, but some people do get anaphylaxis. And it's happened.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what I've seen with the point I'm making is there are some physicians and some pharmacies which, you know, the dosage of ipramone and most of these growth hormone-releasing peptides should be 100 micrograms. That's the max dose to bind the receptor. And, you know, what I've seen is with ipramone, rare, but some people do get anaphylaxis. And it's happened.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what I've seen with the point I'm making is there are some physicians and some pharmacies which, you know, the dosage of ipramone and most of these growth hormone-releasing peptides should be 100 micrograms. That's the max dose to bind the receptor. And, you know, what I've seen is with ipramone, rare, but some people do get anaphylaxis. And it's happened.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And I think that happens when people are pushing it and giving more than they should. And I've heard of that. And they're giving 200, 300, 400 micrograms at a time, which is a big dose. Now what they're getting is the client, the patient is like, oh my gosh, I feel this amazing flushing. It must be working.