Dr. Darren Candow

night shift workers, military pilots, ER doctors, whichever it is, that's where the brain starts to rely on supplementation.

So unfortunately for the brain, creatine really struggles to get through the blood-brain barrier.

But if it does, now you might need longer or higher dosages.

So what about sleep-deprived?

Okay.

So let's say there's five.

There's 10.

What do you think?

It's going to be a lot more.

Here's 15.

Couple studies showed some benefits.

Now let's do 20.

Remember that loading phase?

The best overall studies currently right now that use an MRI for the brain have showed about 20 grams seems to have some effect acutely.

But the two studies last year out of Germany even showed this.

There's 25.

And here's 30.

So a classic study was done last year when they gave 30 grams to a group of young individuals who volunteered to be sleep deprived for 21 hours.

And that level of creatine increased creatine levels in the brain and it offset some of the negative effects.

Remember, that was an acute episode of 21 hours of sleep deprivation.