Dr. Darren Candow

But I've talked to some good colleagues in Canada, and it just seems like weight training is –

it's too intermittent.

Now, when you mentioned CrossFit, that's different.

I'm thinking of the three sets of 10, you move from machine to machine, you rest, you have a CrossFit or something that's really continuous would probably fall in line here of the necessity for creatine.

So that would be a very good study to look at the effects of creatine on the recovery aspects of something like high intensity interval training or

CrossFit, for example, our military type of training, that's really endurance and resistance training.

So you just gave me another idea to run with, but it's logical.

The more intense, the more demanding, I think that's where creatine's anti-inflammatory properties would come into play.

There is.

It's very mixed.

So we don't have a lot of data.

First off, creatine doesn't directly increase protein synthesis, which might be a surprise for a lot of reviewers.

It sort of works in a magical other way, which we can talk about.

But from a muscle breakdown perspective, it seems to reduce something called leucine oxidation primarily in young males.

And that's an indicator of whole body breakdowns.

We've also shown in our lab it reduces 3-methylhistamine, which is another indicator of whole body breakdown.

But nothing is directly shown in the muscle itself.

And for some reason, females don't experience this.

We've looked at it in young and older females.

We don't see the same effect.