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Dr. Dave Vago

👤 Person
453 total appearances

Appearances Over Time

Podcast Appearances

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And that's why psychedelics may actually have a real profound ability to extinguish those types of traumatic memories because they have a dramatic way of inducing neuroplasticity to change that canalization that may have happened over time. over trauma, over intensity. And the only way to get out of that deep groove is another sort of intense kind of experience.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And that's why psychedelics may actually have a real profound ability to extinguish those types of traumatic memories because they have a dramatic way of inducing neuroplasticity to change that canalization that may have happened over time. over trauma, over intensity. And the only way to get out of that deep groove is another sort of intense kind of experience.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And that's why psychedelics may actually have a real profound ability to extinguish those types of traumatic memories because they have a dramatic way of inducing neuroplasticity to change that canalization that may have happened over time. over trauma, over intensity. And the only way to get out of that deep groove is another sort of intense kind of experience.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

That's what happens with exposure therapy as well. When you expose yourself to something that was previously traumatic, it allows you to experience the same sort of sensory modalities of the experience, but reconsolidate them in a more adaptive kind of trajectory.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

That's what happens with exposure therapy as well. When you expose yourself to something that was previously traumatic, it allows you to experience the same sort of sensory modalities of the experience, but reconsolidate them in a more adaptive kind of trajectory.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

That's what happens with exposure therapy as well. When you expose yourself to something that was previously traumatic, it allows you to experience the same sort of sensory modalities of the experience, but reconsolidate them in a more adaptive kind of trajectory.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

Not an easy thing to do, but much easier to do when you're exposed to the same context and then changing the outcome, changing instead of something that was deeply hurtful, you're making something positive out of it. That's how extinction works to replace or compete with existing. There's controversy over whether the actual original trace is actually deleted or that you're just competing

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

Not an easy thing to do, but much easier to do when you're exposed to the same context and then changing the outcome, changing instead of something that was deeply hurtful, you're making something positive out of it. That's how extinction works to replace or compete with existing. There's controversy over whether the actual original trace is actually deleted or that you're just competing

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

Not an easy thing to do, but much easier to do when you're exposed to the same context and then changing the outcome, changing instead of something that was deeply hurtful, you're making something positive out of it. That's how extinction works to replace or compete with existing. There's controversy over whether the actual original trace is actually deleted or that you're just competing

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

with the old memory trace with something more adaptive that's how the memories will change so fundamentally we can say different types of memory episodic declarative procedural these are very different circuitries involved you say that there's a very clear time course of having experience to the point where you consolidate the memory and can recall it and anywhere along that biochemical cascade you can interfere with it

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

with the old memory trace with something more adaptive that's how the memories will change so fundamentally we can say different types of memory episodic declarative procedural these are very different circuitries involved you say that there's a very clear time course of having experience to the point where you consolidate the memory and can recall it and anywhere along that biochemical cascade you can interfere with it

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

with the old memory trace with something more adaptive that's how the memories will change so fundamentally we can say different types of memory episodic declarative procedural these are very different circuitries involved you say that there's a very clear time course of having experience to the point where you consolidate the memory and can recall it and anywhere along that biochemical cascade you can interfere with it

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And in fact, sometimes if you interfere at the right time with the right chemicals, you could really weaken the memory through like protein kinase blocking or like CAMK2 or PKA, PKC. These are different kinase or enzymes that are responsible for helping the memory trace encode.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And in fact, sometimes if you interfere at the right time with the right chemicals, you could really weaken the memory through like protein kinase blocking or like CAMK2 or PKA, PKC. These are different kinase or enzymes that are responsible for helping the memory trace encode.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And in fact, sometimes if you interfere at the right time with the right chemicals, you could really weaken the memory through like protein kinase blocking or like CAMK2 or PKA, PKC. These are different kinase or enzymes that are responsible for helping the memory trace encode.

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And then you can also use those kinds of chemicals to help either facilitate a recall later or to block it even more after the memory has moved into long-term storage. So there's a lot of research that's still happening along those lines to help people How do you reduce the impact of something that may be traumatic?

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And then you can also use those kinds of chemicals to help either facilitate a recall later or to block it even more after the memory has moved into long-term storage. So there's a lot of research that's still happening along those lines to help people How do you reduce the impact of something that may be traumatic?

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

And then you can also use those kinds of chemicals to help either facilitate a recall later or to block it even more after the memory has moved into long-term storage. So there's a lot of research that's still happening along those lines to help people How do you reduce the impact of something that may be traumatic?

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

Is there something you can take right after a traumatic event to reduce the traumatic nature of it affecting later behavior or thoughts? Or how do you stop it from being overwhelming later on when you have to expose to that memory that is intrusive into your everyday life?

Passion Struck with John R. Miles
Dr. Dave Vago on the Neuroscience of Mattering: How to Feel Valued & Seen | EP 565

Is there something you can take right after a traumatic event to reduce the traumatic nature of it affecting later behavior or thoughts? Or how do you stop it from being overwhelming later on when you have to expose to that memory that is intrusive into your everyday life?