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Dr. David Fajgenbaum

πŸ‘€ Speaker
1737 total appearances

Appearances Over Time

Podcast Appearances

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

But they can't typically go after a lot of different diseases because they want to really focus on maximizing profit for the few they can.

3396.947 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So it's not that they're avoiding diseases.

3403.934 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And again, this is

3406.837 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

partly my opinion, but I'm saying it as someone who lost my mom to cancer and who personally has battled these horrible diseases.

3407.718 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

If I was seeing things like people hiding cures, I'd be the first person to talk about it.

3413.645 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I don't see that.

3418.71 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

What I see is that drug companies focus their drugs on whatever diseases they can make the most money on in those eight to 12 years, because they're businesses.

3419.791 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And the moment that drug goes off pad, all research stops.

3428.941 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So what that means is that

3432.746 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

We've got 4,000 drugs.

3434.988 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Well, 80% of them are already generic.

3436.711 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So there's no drug company that has any interest at all in selling more doses of that drug because there's 10 manufacturers and they all sell them for a penny a pill.

3439.917 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And so the problem is that, in my opinion, the problem is not that drug companies are not pursuing these additional uses.

3448.833 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

The problem is that if I discover that

3455.505 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

that ruxolitinib can be useful for a new condition after ruxolitinib goes off patent, like I got to figure out a way to drive forward the science for it.

3458.41 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I got to figure out a way to get, whether it's the government or philanthropists or individuals to donate to do the research because the drug company is like, hey,

3467.024 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I made it like a few years ago, but like 10 other people are making it right now.

3474.256 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And I don't make any money off of that drug.

3478.565 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I'm onto another drug now.

3480.088 View full episode β†’
The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And so I think that that's a problem in our system is that 80% of our drugs are not profitable to find new uses for them.

3481.351 View full episode β†’