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Dr. David Fajgenbaum

๐Ÿ‘ค Speaker
1737 total appearances

Appearances Over Time

Podcast Appearances

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

But they can't typically go after a lot of different diseases because they want to really focus on maximizing profit for the few they can.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So it's not that they're avoiding diseases.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And again, this is

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

partly my opinion, but I'm saying it as someone who lost my mom to cancer and who personally has battled these horrible diseases.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

If I was seeing things like people hiding cures, I'd be the first person to talk about it.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I don't see that.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

What I see is that drug companies focus their drugs on whatever diseases they can make the most money on in those eight to 12 years, because they're businesses.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And the moment that drug goes off pad, all research stops.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So what that means is that

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

We've got 4,000 drugs.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Well, 80% of them are already generic.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So there's no drug company that has any interest at all in selling more doses of that drug because there's 10 manufacturers and they all sell them for a penny a pill.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And so the problem is that, in my opinion, the problem is not that drug companies are not pursuing these additional uses.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

The problem is that if I discover that

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

that ruxolitinib can be useful for a new condition after ruxolitinib goes off patent, like I got to figure out a way to drive forward the science for it.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I got to figure out a way to get, whether it's the government or philanthropists or individuals to donate to do the research because the drug company is like, hey,

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I made it like a few years ago, but like 10 other people are making it right now.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And I don't make any money off of that drug.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I'm onto another drug now.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And so I think that that's a problem in our system is that 80% of our drugs are not profitable to find new uses for them.