Dr. David Sinclair
👤 SpeakerAppearances Over Time
Podcast Appearances
Because the genes that were once turned on correctly in my young cells, that control system, these chemicals on the DNA molecule, the methyls, are getting erased.
So aging is an identity crisis of the cells.
It absolutely is.
Yes.
The genes are still there, in large part.
99.999% of the genes are still there.
The molecule's intact.
But the control systems... The label thing you mentioned.
The label to tell the cell that this gene needs to be on, but this one should always stay off, that gets erased over time.
Why?
We did partially figure that out.
And how do you know?
Well, oh, even better.
The label's...
This is why I love your podcast, Stephen.
You ask the right questions.
There are enzymes that remove these methyl groups and put them back on.
So the cells controlling these things, they shouldn't change, but they do.
And one of the things that messes the system up is major catastrophe in a cell.
And when the cell panics...