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Dr. David Sinclair

๐Ÿ‘ค Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So we could take a mouse and for three weeks we turned on this slime mold cutting protein

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And nothing happened to the mouse at the time.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It's like you don't feel an X-ray.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

You don't feel different when you fly except for maybe jet lag and dehydration.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

But you don't get old suddenly.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Same with the mice.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

They were normal.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

They felt fine.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And that's why at first people said, oh, nothing's going to happen to these mice.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

After three weeks, they were fine.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

But we set in motion a cascade of accelerated aging events that about 10 months later, they were super gray and super old and had all the diseases of aging 50% faster than their twins that we didn't treat.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And you've got photos of those we could show.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Yeah, let's show those.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So if I was to do the experiment in you, I might have to engineer a clone of you, but I could do that.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

I'm not saying that it's ethically right, but theoretically, we could make a clone of you, put in that slime mold gene, turn it on,

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And your clone would be 50% older than you are.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Yeah.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Well, we're exposed to things that cause DNA breaks all the time.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

They happen naturally as the cells try to copy their DNA, but you can accelerate that by getting an X-ray, a CT scan, flying a lot and cosmic rays banging into your DNA.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

I fly all the time.