Dr. David Sinclair
๐ค SpeakerAppearances Over Time
Podcast Appearances
caused me to question that idea that women run out of eggs.
We have published and repeated many times that if you treat old female mice 16 months of age, which is like a 65, 70-year-old human that has long time since given up having offspring,
We can treat the ovaries with a chemical that rejuvenates the eggs that are in the ovary, maybe even produces new ones.
We don't know for sure.
But those 16-month-old mice that stopped having kids probably at least six months ago now start producing healthy offspring again.
Their eggs look young, pristine, compared to the terrible eggs that if you try to harvest some eggs from a mouse that old,
It's hard to find any that look normal.
Their chromosomes are messed up, ripped apart.
They're not going to produce healthy babies.
But we can take those eggs, or at least the ovaries with those eggs in them, and cause them to be young again and make fresh eggs that can produce healthy offspring that live a normal lifespan.
The real question is, will this work in women?
And that's something that I'm keen on testing.
It's harder than you can imagine, actually.
And I've spent a lot of my career since I was 35 aiming to develop a medicine to treat diseases and aging.
And it can go wrong in many ways, even if the science is good and right.
And there's money, there's business, there's laws, there's politics, there's...
business strategies, there's change of leaderships, all sorts of human-introduced variables that can get in the way.
There's patents, and then there's competition and spite that also gets into it.
And I've had to deal with all of those things, including competing against some of the largest pharmaceutical companies in the world who really didn't want me to succeed.
But yeah, it's extremely difficult to make a drug.