Dr. David Sinclair

My body is making less NAD, and it's also destroying the NAD faster than when I was 20.

That's a problem.

And so what we found was that when we fast the yeast or we fast a human, NAD levels go up again.

So fasting raises NAD and makes the sirtuins young again, essentially.

And that preserves the epigenome and it also repairs the DNA better.

You can drink NAD and not much would happen.

So NAD can be taken as a supplement, which is a precursor to NAD.

It's better to take the precursors.

A precursor meaning something that creates it.

Exactly.

There's one called NMN, not to be confused with M&Ms, which will probably not make you live longer.

And there's another one called NR.

NMN is directly converted into NAD.

You put two NMNs together, you get NAD in the cell.

We know this for a fact.

This isn't speculation.

When you give a human NMN by swallowing it, a gram of it, you typically double the amount of NAD in your body.

And we believe, and we have some evidence now in human clinical trials,

that the sirtuins are imparting health benefits, reestablishing the epigenome, lowering body weight, improving inflammation, and even changing cholesterol levels in a positive way in humans.

I've been taking NMN and admitting that publicly for a while now.