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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

This is a protein package.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Each one of these little dots on this little soccer ball is a protein.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

That's now inside the cell.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

This is a little spaceship that opens up

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

and out of that comes the DNA.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

This is a loop of DNA just here.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

This is the DNA package that we put in there, trillions of them.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

One of them gets into one cell and now stays in that cell forever.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So that person,

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

or the monkey or the mouse that we've treated, becomes a transgenic person with genes that we've put in permanently into the back of the eye.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

But they don't do anything until we tell them to.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

That's now just sitting there.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

We've engineered it uniquely and patented the ability to turn on those three genes whenever we want and turn them off again whenever we want.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

We give them doxycycline.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It's used for malaria.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It's used for Lyme disease.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And we're using it in this case to turn these genes on.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So the patients will get their doxycycline.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

We'll give them some probiotics to restore.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Hopefully, we'll restore their microbiome, of course.