Dr. George Papanicolaou

Right, but that hardening of the arteries not only reduces blood flow, but there's this endothelial dysfunction and it's in the endothelial cells that nitrous oxide has its effect.

Right, but that hardening of the arteries not only reduces blood flow, but there's this endothelial dysfunction and it's in the endothelial cells that nitrous oxide has its effect.

Right, but that hardening of the arteries not only reduces blood flow, but there's this endothelial dysfunction and it's in the endothelial cells that nitrous oxide has its effect.

Endothelial cells are the cells that are lining the blood vessels that are inside the penis.

Endothelial cells are the cells that are lining the blood vessels that are inside the penis.

Endothelial cells are the cells that are lining the blood vessels that are inside the penis.

There's multiple reasons. But before we go on to that, I think probably is a good idea. Let me just review quickly because we're going to talk about nitrous oxide. We're going to talk about why Viagra works and other drugs like it. Essentially, what happens is that You have the release of nitrous oxide.

There's multiple reasons. But before we go on to that, I think probably is a good idea. Let me just review quickly because we're going to talk about nitrous oxide. We're going to talk about why Viagra works and other drugs like it. Essentially, what happens is that You have the release of nitrous oxide.

There's multiple reasons. But before we go on to that, I think probably is a good idea. Let me just review quickly because we're going to talk about nitrous oxide. We're going to talk about why Viagra works and other drugs like it. Essentially, what happens is that You have the release of nitrous oxide.

So you release the NO, and the NO has its action on the endothelial cells inside the blood vessels of the penis. It also acts on the corpus cavernosum muscles. And so you get this simultaneous relaxation of those muscles so blood can flow in. Those are the big muscles of the penis so that when they're full of blood, they actually start the erection and maintain the erection.

So you release the NO, and the NO has its action on the endothelial cells inside the blood vessels of the penis. It also acts on the corpus cavernosum muscles. And so you get this simultaneous relaxation of those muscles so blood can flow in. Those are the big muscles of the penis so that when they're full of blood, they actually start the erection and maintain the erection.

So you release the NO, and the NO has its action on the endothelial cells inside the blood vessels of the penis. It also acts on the corpus cavernosum muscles. And so you get this simultaneous relaxation of those muscles so blood can flow in. Those are the big muscles of the penis so that when they're full of blood, they actually start the erection and maintain the erection.

And then you have the small blood vessels Nitrous oxide acts on those at the same time and causes those to constrict. So the blood that flows into the cavernous muscles then stays there as these small veins constrict. And that basically starts the erection and maintains the erection. And what happens is, and that's called tumescence.

And then you have the small blood vessels Nitrous oxide acts on those at the same time and causes those to constrict. So the blood that flows into the cavernous muscles then stays there as these small veins constrict. And that basically starts the erection and maintains the erection. And what happens is, and that's called tumescence.

And then you have the small blood vessels Nitrous oxide acts on those at the same time and causes those to constrict. So the blood that flows into the cavernous muscles then stays there as these small veins constrict. And that basically starts the erection and maintains the erection. And what happens is, and that's called tumescence.

Then you have detumescence when after the ejaculation the penis relaxes. And that's when 5-phosphodiesterase breaks down the compound that was responsible for causing that relaxation and constriction. And when that compound breaks down, the small blood vessels relax and the penis relaxes and becomes flaccid. It's the 5-phosphate diesterase that gets inhibited by Viagra.

Then you have detumescence when after the ejaculation the penis relaxes. And that's when 5-phosphodiesterase breaks down the compound that was responsible for causing that relaxation and constriction. And when that compound breaks down, the small blood vessels relax and the penis relaxes and becomes flaccid. It's the 5-phosphate diesterase that gets inhibited by Viagra.

Then you have detumescence when after the ejaculation the penis relaxes. And that's when 5-phosphodiesterase breaks down the compound that was responsible for causing that relaxation and constriction. And when that compound breaks down, the small blood vessels relax and the penis relaxes and becomes flaccid. It's the 5-phosphate diesterase that gets inhibited by Viagra.

So this is just a little lesson to everybody listening. That's how it works. Viagra blocks the 5-phosphodiesterase, allows this... So basically it increases blood flow and makes the erection stay longer. Because you don't get the breakdown of this thing called cyclic GMP. So that doesn't break down. That maintains the...

So this is just a little lesson to everybody listening. That's how it works. Viagra blocks the 5-phosphodiesterase, allows this... So basically it increases blood flow and makes the erection stay longer. Because you don't get the breakdown of this thing called cyclic GMP. So that doesn't break down. That maintains the...