Dr. George Papanicolaou

We're going to look for the clues in those root causes, those deep dive insights. conditions, and we have all the tools to do that. One, I've seen thousands in my career of patients with ADHD, so I know what to look for. I know what questions to ask to find out about lifestyle, because it all starts with lifestyle. You've got to get lifestyle under control. What does that mean?

That means you've got to be sleeping. You've got to be exercising. You've got to be eating correctly. You have to manage your stress well. And you have to make sure you have good, solid connections and relationship with people. It's very important for people with ADHD. Those connections are very important.

That means you've got to be sleeping. You've got to be exercising. You've got to be eating correctly. You have to manage your stress well. And you have to make sure you have good, solid connections and relationship with people. It's very important for people with ADHD. Those connections are very important.

That means you've got to be sleeping. You've got to be exercising. You've got to be eating correctly. You have to manage your stress well. And you have to make sure you have good, solid connections and relationship with people. It's very important for people with ADHD. Those connections are very important.

So what we do is we always started the gut because there's a very strong gut-brain connection. And if you have an imbalance of that 100 trillion bacteria in your gut called the microbiome, this very important bacteria have to be in balance because they're really good guys of that group make things for our brain. They're also engaged in modulating some of the things in our brain.

So what we do is we always started the gut because there's a very strong gut-brain connection. And if you have an imbalance of that 100 trillion bacteria in your gut called the microbiome, this very important bacteria have to be in balance because they're really good guys of that group make things for our brain. They're also engaged in modulating some of the things in our brain.

So what we do is we always started the gut because there's a very strong gut-brain connection. And if you have an imbalance of that 100 trillion bacteria in your gut called the microbiome, this very important bacteria have to be in balance because they're really good guys of that group make things for our brain. They're also engaged in modulating some of the things in our brain.

So they make our serotonin, 90% of it, up to 90% comes from the gut. Dopamine metabolism can be altered by bacteria in our gut. It can be altered by our immune function in the gut.

So they make our serotonin, 90% of it, up to 90% comes from the gut. Dopamine metabolism can be altered by bacteria in our gut. It can be altered by our immune function in the gut.

So they make our serotonin, 90% of it, up to 90% comes from the gut. Dopamine metabolism can be altered by bacteria in our gut. It can be altered by our immune function in the gut.

So that gut-brain connection is really important because if you have neuroinflammation, I mean, if you have gut inflammation where you have leaky gut that will trigger the immune system into an inflammatory state or even into a state where it's making antibodies against self-tissue, That is going to cause neuroinflammation. It's going to activate glial cells or microglial cells.

So that gut-brain connection is really important because if you have neuroinflammation, I mean, if you have gut inflammation where you have leaky gut that will trigger the immune system into an inflammatory state or even into a state where it's making antibodies against self-tissue, That is going to cause neuroinflammation. It's going to activate glial cells or microglial cells.

So that gut-brain connection is really important because if you have neuroinflammation, I mean, if you have gut inflammation where you have leaky gut that will trigger the immune system into an inflammatory state or even into a state where it's making antibodies against self-tissue, That is going to cause neuroinflammation. It's going to activate glial cells or microglial cells.

And microglial cells, when they're activated by these gut processes, are going to then result in producing cytokines, which are inflammatory. They can also be balanced out and be anti-inflammatory, but oftentimes when we have this disorder of the gut-brain connection, we're having microglial activation and inflammation.

And microglial cells, when they're activated by these gut processes, are going to then result in producing cytokines, which are inflammatory. They can also be balanced out and be anti-inflammatory, but oftentimes when we have this disorder of the gut-brain connection, we're having microglial activation and inflammation.

And microglial cells, when they're activated by these gut processes, are going to then result in producing cytokines, which are inflammatory. They can also be balanced out and be anti-inflammatory, but oftentimes when we have this disorder of the gut-brain connection, we're having microglial activation and inflammation.

And so we did a stool test, and we also tested Claire for leaky gut. And the leaky gut test that I use also measures histamine levels in the gut and the enzyme that breaks down histamine levels in the gut. And in her case, she had a mild imbalance of her bacteria, but she had an overgrowth of candida, which is a yeast or a fungus. probably from the fact that she was eating all that sugar.

And so we did a stool test, and we also tested Claire for leaky gut. And the leaky gut test that I use also measures histamine levels in the gut and the enzyme that breaks down histamine levels in the gut. And in her case, she had a mild imbalance of her bacteria, but she had an overgrowth of candida, which is a yeast or a fungus. probably from the fact that she was eating all that sugar.

And so we did a stool test, and we also tested Claire for leaky gut. And the leaky gut test that I use also measures histamine levels in the gut and the enzyme that breaks down histamine levels in the gut. And in her case, she had a mild imbalance of her bacteria, but she had an overgrowth of candida, which is a yeast or a fungus. probably from the fact that she was eating all that sugar.

So that lifestyle of nutrition does play an important role in creating inflammation in the gut. Because now you've allowed candida to grow. Candida is highly immunogenic, highly inflammatory, and will definitely trigger the immune response and neuroinflammation we just talked about. But she also had an imbalance where she did not have enough of that enzyme to break down histamine.