Dr. Jeff Bland

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312 appearances 4 recordings 1 series first heard Nov 2024 last heard Jun 2025

Dr. Jeff Bland’s voice in public audio — every appearance, attributed to the second.

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The Dr. Hyman Show · How Jeff Bland Reversed His Biological Age at 79 (Part 1) · 28 May 2025 podcast

So it has a specificity, but it's not the memory effect that you have with the adaptive immune system and antibodies. But I think that what we recognize, and this is an important new aha, is that you can fairly quickly train the innate immune system to be more resilient. It doesn't take months. And how do you do that? Here is where the polyphenols play a principal role.

This may be, as you said earlier, this list of nutrients that have only gotten a page or two publication in nutrition textbooks because we weren't considered to be essential nutrients, this whole flavonoid family of compounds. Now we're seeing they play principal roles in priming the innate immune system and regulating the genes that are associated with immune defense. This is all new discoveries.

I'm talking about the last five years. So this is like aha stuff. that then makes diets become ever more important for how we therapeutically modulate our immune systems.

Yes, the so-called immunosenescence that you were talking about, inflammation. Yeah. And so now we're starting to recognize that when you get this secretory phenotype of inflammation, because the body has started to collect injury to immune cells and other cells, it gets locked into the state of being constantly, that's where the immune system is aged more than your years of birthdays.

And you have an accelerated series of aging that can appear as a brain dysfunction, as a cardiac dysfunction, as diabetes. It can present itself. And by the way, We now recognize that this new class of drugs that we call GLP-1 agonists that are being used for diabetes and for obesity, those affect the immune system through the adipocyte, the fat cells.

So now we're starting to learn that these are all interconnected into another system, which is the gut connected to the fat cell, connected to the brain, connected to the immune system. And so when we're giving GLP-1 agonist drugs, we're also having a therapeutic influence on that system as well.

Exactly right.

And the answer is yes. Those clinical studies have been done and published showing exactly what you said, that it has an effect on B cells and has an effect on Tregs, the thymus-dependent regulatory cells.

And we now know the genes that actually are regulated by specific flavonoids that ultimately affect the personality of those immune cells that then speak to your B cells to change your antibodies. All this is a giant system that interrelates you to your diet and your lifestyle.

That's exactly the paradigm shift that I'm so excited that I'm still involved with this field. It has been my wish and dream that I would still be around in this field when this ultimate shift in paradigm would occur. I knew it would ultimately occur. I didn't know when. And we're living it right now. This is like no period of history in changing the whole fundamental paradigm of health care.

Anybody that's practicing from that which it was is an artifact. That which it will be is where we need to be concentrating our attention. Because these are modifiable. These are executable. These deliver real results. Asking the right questions and getting the right answers. Not just looking for when you get a disease. That is old school thinking.

we have to be looking at the prognosis, not the diagnosis, of where these are going. What's their trajectory? And that is what we're seeing as food as medicine is one of the therapeutic tools.

Because lo and behold, we're relearning what nature has been trying to tell us, the wisdom of nature, that these modulate these functions in our body in real ways, not in decades of living, but in months of living. In months, you can change your genetic expression patterns.

Well, everything you said, I 100% agree with one variation. Please. You said medicine will practice. Medicine is being practiced by enlightened practitioners. Well, sure.

You know how long it takes to understand anatomy, physiology, pathology, cytology. Those are all skills that are really important to understand what we know about the organizational structure of the body.

And it takes quite a while to get competent about those understandings, upon which you then build this new enlightened architecture of how we're going to use those things that we've learned that are given to create a more dynamic process that will take us to health.

and having 50 years in my life of measuring my biomarkers on a routine basis, and now having the access of Function Healthy provides many more biomarkers, I can see the important value of layering on top of my traditional background and training of anatomy, physiology, pathology, that I probably wouldn't have understood in the absence of understanding the body. So all this fits together.

And your daughter, I know, as with many other practitioners, as they gain more experience in life and practice, will see that there are other things they need to learn.

I think you just said a drop the mic. I mean, that is the fundamental raison d'etre for functional medicine is finding an operating system that can deliver on that opportunity because that opportunity is in all of us, in our genes. Our genes have that potential if we give them half the chance to express it.

I think that what's happening right now, and Mark, you're an exemplar of this, is the use of these digital communication tools to be able to accelerate the adoption of these concepts so we don't wait at the roadblock of somebody holding back on the information because they are the gatekeeper. And that accessibility of information, and truth wills out, I believe.

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