Dr. Jeff Karp
speaker
137 appearances
1 recordings
1 series
first heard Nov 2024
last heard Nov 2024
Dr. Jeff Karp’s voice in public audio — every appearance, attributed to the second.
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Appearances
I'm so excited to be here. Thank you so much.
Yeah, I am. I'm at the Brigham and Women's Hospital and I'm still wearing my bike shoes.
Yeah, thank you for that question. And thank you for tuning into this. Oh my goodness, wow. There are tools I'm going to share today that have literally transformed my life. They've transformed so many moments that have taken me from being in a rut, from hitting a plateau.
from being disconnected from my family and friends, from being on a path where I just feel like I'm trapped in a cage and life is out of control. And today, I'm going to share tools that have literally lit up my life and allowed me to get on a path of intentionality, infused creativity,
into every day to help me lead with curiosity, to connect deeply with the people that I love and care about, and to attune to the rhythms of life and connect deeply with nature.
Absolutely. So my lab is literally focused on the process of medical problem solving. It's an ever-evolving process. It's highly iterative. And the major focus is how can we make academic discoveries and move them as quickly as possible to patients. And we do this
Based on a lot of different things, one is the lab composition, which I'll talk a little bit about today, and just how we approach problems, how we infuse fresh energy, how we disrupt linear thinking and single possibilities that we might find ourselves within. And this has allowed us to create all sorts of technologies that are in clinical trials and have actually made it to patients.
For example, we developed a nasal spray in the lab that we demonstrated could neutralize like 99.99% COVID-19, H1N1, influenza A and B. a form of pneumonia. So that's one example. We developed a needle that can stop in between the layers of the eye to deliver gene therapy to the back of the eye. It's really difficult to get drugs to the back of the eye for macular degeneration.
And that's en route to a clinical trial We've developed therapies to annihilate cancer, therapies for osteoarthritis. And it's really like a playground, if you will. People from all over the world, people with tons of different experiences and backgrounds and expertise. But we really have a North Star for every project, which is to help patients as quickly as we can.
I think creativity is one of these life forces. It's something that we can tap into. It's something that we are all born with. It's something that is flattened by our society and perhaps through the education system, depending on where we were educated and the circumstances. But I think with this sort of algorithmic lifestyle that we all lead, So many thoughts in my mind. I'm like, whoa.
I'm like, yeah, because creativity, it's like, to me, it's just so exciting because we all have this ability to tap into creativity. And when we do, we surprise ourselves. It's literally like this thing that just lights us up when we tap into it. And I think that it's magnetic.
there's gravity to it when somebody is being creative it just attracts other people like everyone wants to like oh what are you doing like oh that's so interesting how'd you think of that like something magical about creativity and so for my laboratory you know it's like it's one thing to try to make academic discoveries it's another to then take those discoveries and turn them into products that can help patients so like the level of difficulty just escalates yeah
And so I've spent a lot of time sort of trying to figure out and actually experiment in my laboratory with processes to maximize creativity. So one of the things that I've noticed is that the lab composition is critical for creativity. Okay. And so I've tried intentionally on purpose to limit the overlap in expertise. Most laboratories, you have the same kind of expert.
Everyone in the lab has the same expertise. What I've noticed is that if we minimize the overlap, that we can really leverage the power of thinking differently. And that's sparks of creativity just start flying. In the lab, we have chemists, we have material scientists, we have biologists, immunologists, but we've also had a gastrointestinal surgeon, a cardiac surgeon.
We've had a dentist in the lab. It's constantly changing. And I think when you start interacting with people who think differently, who have different skills, we've had people from 30 different countries in the lab. And when you're from a different country, you have a different education system. So you You think differently, you have different wiring, you have different experiences.
And to me, that's how you start to generate the sparks of creativity. And something else that I experimented with in my lab, which actually was like transformational, was I set up, and I hadn't seen this before, but I just was like, I need to somehow figure out how to get things more creative and people to connect. And so I thought, okay, presentation competitions. So I came up with this idea.
Yes.
Yes. And then there's some guideposts. So you can't present on your research. You have to present on something that is one of your passions or one of your interests.
Or something you're curious about. I love that. And the goal is to take risks. This is a safe environment where no one's going to be shamed. And everyone's in the same boat from like a high school student to a PhD student to a postdoc to young faculty. And everybody presents for three minutes.
And then afterwards, the questions are focused on constructively, what could you do to improve your talk? What did you really like about the talk? And then at the end, I give prizes for people. Everyone votes. I don't vote. And who gave the best presentation? Who took the most risk? And who gave the best constructive feedback? And we've had people in the lab couldn't have expected this.
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