Dr. Jen Gunter

There's also some that say there's a higher risk.

not significantly high to any way to panic who's on it, but so we have conflicting data.

And the long-term data we have from some randomized trials doesn't show any benefit.

So, you know, there's the KEEPS trial, which has some long-term follow-up data.

There's WHIMSY, which was the young, I can't remember, the acronyms, man, like, you know what I mean?

So that was an ancillary branch for the Women's Health Initiative that was followed up.

And so we don't have data.

There's no data to show that in the short term for people who are in menopause, that menopause hormone therapy improves cognition when that's a primary outcome that's tested.

And we don't have data to show that it reduces the risk of dementia.

What we're getting more data about is that it seems that women who have more hot flashes may be at higher risk, right?

So now we're starting to see a signal.

Why is that?

Could it be that the hot flash is having a negative effect on the brain?

That's a possibility.

Exactly, could it be the impact on sleep?

Could it be that people who have hot flashes and people who get dementia have a shared neurobiology?

Maybe they have some type of autonomic instability.

Maybe there's a vascular issue.

So we're at the point where we're like, hmm, maybe we're kind of drilling down.

And so, you know, there are studies looking at, you know, do we need to use estrogen or could we use a non-hormonal?