Dr. Jocelyn Wittstein

And estrogen is an anti-inflammatory hormone.

I just, I sort of started thinking,

just putting these pieces together and then these other complaints that they're having all kind of together.

And I just, I think the thing that first, I mean, down the path was the effect of aromatase inhibitors.

And I ended up talking to Anne about this and I was like, this has to be

a symptom of menopause.

So this was like actually during COVID.

I spent hours and hours and hours, days and days and days manually doing chart reviews of like thousands of charts.

As you know, use of menopausal hormone therapy is less than 5% in women in the United States.

Now in our population, because I work with women's health doctors who are... Ahead of the curve.

I would say on top of things.

Not to say other people are on top of things, just they're, I think, have a higher percentage.

I think it's about 8 or 9%.

Right.

Right.

So, but even so, if you only have 8 or 9% of people on hormone therapy and the rest are not, and you have, you know, several thousand women that you're looking at, it's hard to get the numbers you need statistically.

So we need to do more research on this.

And what we ended up finding in our study was that women who used menopausal hormone therapy that included estradiol, systemic, not just local,

had half the risk of developing frozen shoulder as compared to those who didn't.

However, we approached statistical significance, but didn't reach it.