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Dr. John Kruse

👤 Person
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And, you know, I've run 100 and my heart, I think, is still beating. So we know things we thought we know at one point.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And, you know, I've run 100 and my heart, I think, is still beating. So we know things we thought we know at one point.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Common cardiovascular effects of not just the stimulants, but the non-stimulants that are affecting norepinephrine, so Welbutrin, Cymbalta, Modafinil, it's less clear, and we can get into that when we talk about Modafinil, but clearly methylphenidate, amphetamine, on average increase, at therapeutic doses, increase Heart rate, a few points. Increased blood pressure, a few points.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Common cardiovascular effects of not just the stimulants, but the non-stimulants that are affecting norepinephrine, so Welbutrin, Cymbalta, Modafinil, it's less clear, and we can get into that when we talk about Modafinil, but clearly methylphenidate, amphetamine, on average increase, at therapeutic doses, increase Heart rate, a few points. Increased blood pressure, a few points.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Common cardiovascular effects of not just the stimulants, but the non-stimulants that are affecting norepinephrine, so Welbutrin, Cymbalta, Modafinil, it's less clear, and we can get into that when we talk about Modafinil, but clearly methylphenidate, amphetamine, on average increase, at therapeutic doses, increase Heart rate, a few points. Increased blood pressure, a few points.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But part of that obscures that probably 80% of people don't have any change and maybe 20% have maybe a more slightly significant change. So we know that there's some impact there. We know there's some people with extremely rare genetic underlying conditions, usually related to the neurologic wiring of the heart, who are particularly vulnerable to dropping dead from a stimulant.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But part of that obscures that probably 80% of people don't have any change and maybe 20% have maybe a more slightly significant change. So we know that there's some impact there. We know there's some people with extremely rare genetic underlying conditions, usually related to the neurologic wiring of the heart, who are particularly vulnerable to dropping dead from a stimulant.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But part of that obscures that probably 80% of people don't have any change and maybe 20% have maybe a more slightly significant change. So we know that there's some impact there. We know there's some people with extremely rare genetic underlying conditions, usually related to the neurologic wiring of the heart, who are particularly vulnerable to dropping dead from a stimulant.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Almost every year there's a well-trained athlete, either a professional player or more often a high school or college player, who will take cocaine, take Ritalin, take prescription stimulant, and drop dead of a heart attack. The risk of that is so uncommon. This is 15 years ago. When Adderall XR came out, the Canadian government was worried enough about this risk

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Almost every year there's a well-trained athlete, either a professional player or more often a high school or college player, who will take cocaine, take Ritalin, take prescription stimulant, and drop dead of a heart attack. The risk of that is so uncommon. This is 15 years ago. When Adderall XR came out, the Canadian government was worried enough about this risk

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Almost every year there's a well-trained athlete, either a professional player or more often a high school or college player, who will take cocaine, take Ritalin, take prescription stimulant, and drop dead of a heart attack. The risk of that is so uncommon. This is 15 years ago. When Adderall XR came out, the Canadian government was worried enough about this risk

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

that they banned Adderall XR for almost a year, and because they have a comprehensive medical system that could look more extensively at the numbers, and this was looking at kids, the percentage of kids who dropped dead with Adderall was tiny, and not just tiny, it was lower than the kids who aren't on Adderall who dropped dead of a heart attack.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

that they banned Adderall XR for almost a year, and because they have a comprehensive medical system that could look more extensively at the numbers, and this was looking at kids, the percentage of kids who dropped dead with Adderall was tiny, and not just tiny, it was lower than the kids who aren't on Adderall who dropped dead of a heart attack.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

that they banned Adderall XR for almost a year, and because they have a comprehensive medical system that could look more extensively at the numbers, and this was looking at kids, the percentage of kids who dropped dead with Adderall was tiny, and not just tiny, it was lower than the kids who aren't on Adderall who dropped dead of a heart attack.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So part of it is, if you're in this rare genetic condition, Almost always there's family members or you've had some other near-death or syncopal episode where you passed out. So history taking of the individual and family history. And if you're at all worried or concerned, you can do EKGs, which detect most of those electrical abnormalities.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So part of it is, if you're in this rare genetic condition, Almost always there's family members or you've had some other near-death or syncopal episode where you passed out. So history taking of the individual and family history. And if you're at all worried or concerned, you can do EKGs, which detect most of those electrical abnormalities.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So part of it is, if you're in this rare genetic condition, Almost always there's family members or you've had some other near-death or syncopal episode where you passed out. So history taking of the individual and family history. And if you're at all worried or concerned, you can do EKGs, which detect most of those electrical abnormalities.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But the cardiology, and lots of my colleagues practice maybe a more conservative cover-your-ass medicine approach where everyone has to have an EKG before they're on a stimulant. But even the cardiology associations have said that seems to be a waste of resources. Absolutely do a thorough history.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But the cardiology, and lots of my colleagues practice maybe a more conservative cover-your-ass medicine approach where everyone has to have an EKG before they're on a stimulant. But even the cardiology associations have said that seems to be a waste of resources. Absolutely do a thorough history.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

But the cardiology, and lots of my colleagues practice maybe a more conservative cover-your-ass medicine approach where everyone has to have an EKG before they're on a stimulant. But even the cardiology associations have said that seems to be a waste of resources. Absolutely do a thorough history.