Dr. Joshua Sterling

We're still accruing for the pilot phase.

I did a couple of test runs with patients that were outside of the trial, so not on protocol as we were trying to figure it out.

The one patient that kind of sparked everything was an elderly gentleman with MS who kept having recurrent infectious stones.

When I met him, he was on ertapenem a couple times a week with his ID doctor.

So we got rid of all the stones, and then I started him on a weekly, or not weekly, a monthly irrigation where we put 150 cc's into the bladder and kind of plant his SP tube, and he could hold it for up to five minutes depending on just kind of irritation in the bladder.

Sometimes he wouldn't last that long.

And we went from multi-drug resistant E. coli to just mixed flora in four months.

Wow, that's impressive.

Yeah.

yeah and he kind of got lost to follow up and you know there was a couple months i think it was five months where he wasn't getting anything and then you know the cycle started again but you know definitely shifted and moved the needle for him and you know so we're kind of seeing with these other patients a definite improvement in their symptoms and at least if they're still having the irritative symptoms that we know all these patients do

Now, when they go to the emergency room, it's not going to immediately grow back something and they have a better chance of not getting into that cycle where they're just constantly on antibiotics.

And the other patient that I had running through is somebody who had IBS and basically doesn't have enough intestines to take oral antibiotics.

And so every time something grows out, she needs a PICC line or to do kind of infusions at home.

So it's just kind of another patient.

What can we do to shift it?

And she's still growing out.

She moved on four treatments for her.

but it's gone from completely symptomatic to now asymptomatic bacteria.

So again, even if we're decreasing the frequency that she's having, the infusions that she needs, it is definitely helping with her overall quality of life.

I haven't switched everything to stentless, but I have for a bunch.