Dr. Ken Spielvogel

How did GLP one medications even end up in the addiction conversation in the first place?

It's a good question.

So there, you know,

ozempic which was really the first first let's answer this question you know why are we injecting a drug once a week versus just taking a pill right okay i mean why wouldn't we just take a pill the problem was with the early versions the oral versions is that the absorption in the intestine was really variable so if you ate anything you had to be fasting

You couldn't eat for at least 30 minutes afterwards.

You had to take it at the same time every day.

How many people can do that?

Plus, if you're going to think about the idea of using it in addiction and recovery, people being on a regimented schedule of taking medications when they're really just starting to piece their life together, unless they have an assistant that's giving them the medication on time.

It's never happened.

It's not happening.

And most people are super non-compliant when it comes to oral medications.

So the idea with compliance, with getting people to take a medication, to have it be reliable, the less frequent you have to use it, the better.

Okay, so an injection once a week, a good start.

And what they saw was with people using Ozempic was they reported that they just had not only like feeling fuller, all metabolic numbers looking better, improved insulin resistance, lowering their hemoglobin A1C, improving their cholesterol panel, maybe even a secondary effect of lowering blood pressure is that they had less craving for food.

And then when you looked at obese alcoholics, opioid addicts in particular, you saw that they reported less desire to use, less desire to drink, less desire to smoke.

So that just- That's what's happening to me.

But on the Zepound, because the Ozempic made me nauseous.

What's the difference between Ozempic and Zepound

And why was I having such a hard time with the Ozempic?

But the Zepound is not a problem at all.