Dr. Kerry Courneya

So the risk of fracture in patients with metastatic bone disease

And again, we just have to work around that with the exercise prescription, but that's a risk we have to be aware of.

That's a great question.

And the problem is we haven't sorted that out.

So there's no sort of pattern yet to be, okay, it's exacerbating pancreatic cells, but not liver cancer cells.

or that it's the high intensity exercise making things worse versus low intensity, or when we look at the cancer with this type of mutations, or if we do forced exercise versus voluntary exercise.

So people have looked at all that to try and sort out

these studies.

It's about 10% of the studies.

So the majority show exercise slows the growth and spread.

About 10% are showing this tumor is growing more quickly.

But there's no pattern to it that we can say, ah, we think this is what's driving it.

Exactly.

Yeah, that's right.

All those factors are kind of being looked at, but there's no pattern yet that would suggest it.

So it's just something to be aware of as we do these types of studies.

Yeah, exactly.

So that's, I think one of the key things is this exacerbation of symptoms.

We have to work around the side effects and the symptoms that patients are experiencing to make sure the exercise is safe and tolerable for them.

So, you know, if patients are experiencing peripheral neuropathy, some patients experience issues with ataxia, balance and stuff as well.