Dr. Layne Norton

And for them, that's not going to work very well, right?

And so the other thing that gets brought up a lot is kind of autophagy and then longevity.

And so what I'll say is,

Yes, time-restricted eating raises autophagy, but so does calorie restriction and so does exercise.

Yeah, all true.

And also with autophagy, I think – again, this is where it's like using terms as blanket good, bad.

I mean autophagy is elevated in some cancers.

It's elevated in some wasted diseases.

I mean we're talking about lysosomal protein degradation essentially.

And so –

You know, I just try to remind people like thinking about stuff in black and white is probably not the way you want to do it, right?

Now, I think the issue with trying to understand something like autophagy is really you'd have to almost do studies looking at autophagy where you're equating like weekly calories, like if you want to get in the more extreme versions of fasting and then looking, okay, what is the overall net effect?

Because, all right, let's say you're doing alternate day fasting, right?

Like a more extreme version of fasting.

Absolutely.

I have no doubt that on your day of fasting, your autophagy is going up.

But then if we are equating calories, right, you're going to be eating much more on your feeding day than a person who's just eating the same amount of calories every single day is if we're equating apples to apples, right?

And so when you're eating more, that tends to reduce autophagy.

And so what's the overall net effect, right?

I don't know.