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Dr. Layne Norton

👤 Person
4445 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

But no, when you read how it was designed, I can easily say, like, I remember there was a, somebody sent me a study and said, well, how does this fit with your data, which... They were comparing rice versus whey protein and found that both stimulated protein synthesis to the same degree. And I said, well, they used 40 grams of protein.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

But no, when you read how it was designed, I can easily say, like, I remember there was a, somebody sent me a study and said, well, how does this fit with your data, which... They were comparing rice versus whey protein and found that both stimulated protein synthesis to the same degree. And I said, well, they used 40 grams of protein.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Like if you get protein high enough, you can max out protein synthesis regardless of the form of protein you're using. And so that's just like one of those examples, right? So when I'm looking through this stuff, I'm looking at, OK, does there seem to be a consensus in the data? And then is it like in these meta-analyses, does the inclusion criteria make sense?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Like if you get protein high enough, you can max out protein synthesis regardless of the form of protein you're using. And so that's just like one of those examples, right? So when I'm looking through this stuff, I'm looking at, OK, does there seem to be a consensus in the data? And then is it like in these meta-analyses, does the inclusion criteria make sense?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Like if you get protein high enough, you can max out protein synthesis regardless of the form of protein you're using. And so that's just like one of those examples, right? So when I'm looking through this stuff, I'm looking at, OK, does there seem to be a consensus in the data? And then is it like in these meta-analyses, does the inclusion criteria make sense?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And then if there's no real agreement amongst the meta-analyses, then I'm looking at, OK, what do the most tightly controlled studies show, like in the randomized control trials? And then I'm kind of like basing opinion off that. But, you know, the hierarchy of evidence, the pyramid, you got meta-analysis, systematic reviews, randomized control trials.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And then if there's no real agreement amongst the meta-analyses, then I'm looking at, OK, what do the most tightly controlled studies show, like in the randomized control trials? And then I'm kind of like basing opinion off that. But, you know, the hierarchy of evidence, the pyramid, you got meta-analysis, systematic reviews, randomized control trials.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And then if there's no real agreement amongst the meta-analyses, then I'm looking at, OK, what do the most tightly controlled studies show, like in the randomized control trials? And then I'm kind of like basing opinion off that. But, you know, the hierarchy of evidence, the pyramid, you got meta-analysis, systematic reviews, randomized control trials.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

You have cohort data, epidemiology, and then animal studies tend to get kind of lumped in together. And then you got like case studies and so on and so forth, right? And so all that stuff is valid. It's all valid. I think where I spend a lot of time on social media is, for example, I'll give you a great example.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

You have cohort data, epidemiology, and then animal studies tend to get kind of lumped in together. And then you got like case studies and so on and so forth, right? And so all that stuff is valid. It's all valid. I think where I spend a lot of time on social media is, for example, I'll give you a great example.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

You have cohort data, epidemiology, and then animal studies tend to get kind of lumped in together. And then you got like case studies and so on and so forth, right? And so all that stuff is valid. It's all valid. I think where I spend a lot of time on social media is, for example, I'll give you a great example.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Someone saying, well, you don't want to eat cruciferous vegetables because they have isocyanthanates in them, which can bind to iodine. And that is going to impair your thyroid function, lower your metabolic rate and cause you weight gain. And so. That's a pathway. That's a mechanism. Is it possible? I suppose it is possible, right? That pathway does exist.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Someone saying, well, you don't want to eat cruciferous vegetables because they have isocyanthanates in them, which can bind to iodine. And that is going to impair your thyroid function, lower your metabolic rate and cause you weight gain. And so. That's a pathway. That's a mechanism. Is it possible? I suppose it is possible, right? That pathway does exist.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Someone saying, well, you don't want to eat cruciferous vegetables because they have isocyanthanates in them, which can bind to iodine. And that is going to impair your thyroid function, lower your metabolic rate and cause you weight gain. And so. That's a pathway. That's a mechanism. Is it possible? I suppose it is possible, right? That pathway does exist.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Iodine is important for thyroid function. Isocyanthanates do bind to iodine. You can take any food, even organic food, and you can find a compound in it. That if you fed it in a high dose, it would have weird effects, right? And so the question is not if you eat something, are there compounds in it that maybe activate negative biochemical pathways? The question is what is the overall outcome?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Iodine is important for thyroid function. Isocyanthanates do bind to iodine. You can take any food, even organic food, and you can find a compound in it. That if you fed it in a high dose, it would have weird effects, right? And so the question is not if you eat something, are there compounds in it that maybe activate negative biochemical pathways? The question is what is the overall outcome?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

Iodine is important for thyroid function. Isocyanthanates do bind to iodine. You can take any food, even organic food, and you can find a compound in it. That if you fed it in a high dose, it would have weird effects, right? And so the question is not if you eat something, are there compounds in it that maybe activate negative biochemical pathways? The question is what is the overall outcome?

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And so when these pathways are promoted versus let's see if we actually have randomized control trials in humans. that measure what we actually care about. And so we do have, like in that particular case, we have randomized control trials looking at, okay, cruciferous vegetable intake and thyroid function. And there's no difference in the outcome.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And so when these pathways are promoted versus let's see if we actually have randomized control trials in humans. that measure what we actually care about. And so we do have, like in that particular case, we have randomized control trials looking at, okay, cruciferous vegetable intake and thyroid function. And there's no difference in the outcome.

Huberman Lab
Tools for Nutrition & Fitness | Dr. Layne Norton

And so when these pathways are promoted versus let's see if we actually have randomized control trials in humans. that measure what we actually care about. And so we do have, like in that particular case, we have randomized control trials looking at, okay, cruciferous vegetable intake and thyroid function. And there's no difference in the outcome.