Dr. Layne Norton

Right.

Correct. So I'm trying to explain it because it makes more sense when people kind of go this way. you never reach zero, but it keeps getting incrementally closer on the other end. I don't think protein synthesis ever maxes out. I just think the increment of increase becomes so small that practically there's no difference and you wouldn't see a difference in outcome. Right.

Correct. So I'm trying to explain it because it makes more sense when people kind of go this way. you never reach zero, but it keeps getting incrementally closer on the other end. I don't think protein synthesis ever maxes out. I just think the increment of increase becomes so small that practically there's no difference and you wouldn't see a difference in outcome. Right.

Correct. So I'm trying to explain it because it makes more sense when people kind of go this way. you never reach zero, but it keeps getting incrementally closer on the other end. I don't think protein synthesis ever maxes out. I just think the increment of increase becomes so small that practically there's no difference and you wouldn't see a difference in outcome. Right.

And so I think that, you know, one, you know, there's debate over is at 1.6 grams per kg, 2.4 grams per kg. I, and there's even been a meta regression that showed up to 3.3 grams per kg had benefits and, I think a lot of this is with protein synthesis, you're looking for small differences between small numbers. It's not a very sensitive analysis, to be quite honest with you.

And so I think that, you know, one, you know, there's debate over is at 1.6 grams per kg, 2.4 grams per kg. I, and there's even been a meta regression that showed up to 3.3 grams per kg had benefits and, I think a lot of this is with protein synthesis, you're looking for small differences between small numbers. It's not a very sensitive analysis, to be quite honest with you.

And so I think that, you know, one, you know, there's debate over is at 1.6 grams per kg, 2.4 grams per kg. I, and there's even been a meta regression that showed up to 3.3 grams per kg had benefits and, I think a lot of this is with protein synthesis, you're looking for small differences between small numbers. It's not a very sensitive analysis, to be quite honest with you.

And, again, we would never be able to pick out those differences. And I'm thinking about there was a study by Stu Phillips who, if people don't know who Stu Phillips is, he's the best researcher going in protein metabolism right now. But one of the best. Sorry, I don't want to tick anybody off. And he did a study probably 15 years ago where they gave people different levels of egg protein.

And, again, we would never be able to pick out those differences. And I'm thinking about there was a study by Stu Phillips who, if people don't know who Stu Phillips is, he's the best researcher going in protein metabolism right now. But one of the best. Sorry, I don't want to tick anybody off. And he did a study probably 15 years ago where they gave people different levels of egg protein.

And, again, we would never be able to pick out those differences. And I'm thinking about there was a study by Stu Phillips who, if people don't know who Stu Phillips is, he's the best researcher going in protein metabolism right now. But one of the best. Sorry, I don't want to tick anybody off. And he did a study probably 15 years ago where they gave people different levels of egg protein.

And they looked at 5, 10, 20, and 40 grams of egg protein. And their conclusion was that 20 grams of egg protein maximized the protein synthesis response. But that's because straight down the line, if there's a p-value of more than .05, you can't say there's a difference, right? But if you looked at the absolute difference between 20 and 40 grams, I think it was like 11%.

And they looked at 5, 10, 20, and 40 grams of egg protein. And their conclusion was that 20 grams of egg protein maximized the protein synthesis response. But that's because straight down the line, if there's a p-value of more than .05, you can't say there's a difference, right? But if you looked at the absolute difference between 20 and 40 grams, I think it was like 11%.

And they looked at 5, 10, 20, and 40 grams of egg protein. And their conclusion was that 20 grams of egg protein maximized the protein synthesis response. But that's because straight down the line, if there's a p-value of more than .05, you can't say there's a difference, right? But if you looked at the absolute difference between 20 and 40 grams, I think it was like 11%.

And if you look at the graph, it almost looks like the start of an asymptote, right? Now, this was one study, wasn't a huge subject number. But that's kind of where my personal thoughts land on it, that kind of also support this, okay, 100 grams at a meal could still be utilized, is I'm not sure if there's a max out. I think there's a practical max out where you get to a point where –

And if you look at the graph, it almost looks like the start of an asymptote, right? Now, this was one study, wasn't a huge subject number. But that's kind of where my personal thoughts land on it, that kind of also support this, okay, 100 grams at a meal could still be utilized, is I'm not sure if there's a max out. I think there's a practical max out where you get to a point where –

And if you look at the graph, it almost looks like the start of an asymptote, right? Now, this was one study, wasn't a huge subject number. But that's kind of where my personal thoughts land on it, that kind of also support this, okay, 100 grams at a meal could still be utilized, is I'm not sure if there's a max out. I think there's a practical max out where you get to a point where –

hey, you're like slamming down 50 grams more protein for 0.0001% more protein synthesis. It doesn't make sense. But yeah, we'll never be able to – I doubt we'll be able to pick those numbers out in actual scientific experiments. And the other thing to keep in mind with this whole protein metabolism picture is we're really only talking about one side of this equation. So –

hey, you're like slamming down 50 grams more protein for 0.0001% more protein synthesis. It doesn't make sense. But yeah, we'll never be able to – I doubt we'll be able to pick those numbers out in actual scientific experiments. And the other thing to keep in mind with this whole protein metabolism picture is we're really only talking about one side of this equation. So –

hey, you're like slamming down 50 grams more protein for 0.0001% more protein synthesis. It doesn't make sense. But yeah, we'll never be able to – I doubt we'll be able to pick those numbers out in actual scientific experiments. And the other thing to keep in mind with this whole protein metabolism picture is we're really only talking about one side of this equation. So –

Net gain or loss of skeletal muscle mass is the balance between protein synthesis and protein degradation. And most of us protein researchers just kind of stick our fingers in our ears and go la, la, la, la when it comes to protein degradation because it's so incredibly hard to measure.