Dr. Layne Norton

I mean it's so funny when people say to me, well, I have a slow metabolism.

That's why I want to take Ozempic.

I'm like, well, if you have a slow metabolism, Ozempic is not going to help because it doesn't increase your metabolic rate.

It is a very powerful appetite suppressant.

So in this study, they looked at BMR, total energy expenditure, and found that basically people's lean body mass explained about 70% to 80% of the variance in BMR and total energy expenditure.

You can almost draw like a straight line through it.

Yeah.

So –

lean mass, just be clear, lean mass and skeletal muscle mass often get used interchangeably and they're not.

Lean mass is a relatively good proxy for skeletal muscle mass, but lean mass versus fat mass is a two compartment model.

Like for DEXA, for example, you'll get fat mass.

So literally all fatty tissues will go into a bucket and then everything else goes into a bucket.

So we're talking bones, skin, undigested food, fluid, like all that kind of stuff.

Um, but in general, uh, adipose is a relatively, it's not an inert tissue.

We used to think it was inert tissue.

We know that's not the case anymore.

But it has a very low energy expenditure relative to other lean tissues.

And actually, skeletal muscle doesn't have a super high energy expenditure for a lean tissue.

It's actually one of the slowest, if not the slowest.

Like liver and gut tissues have a much higher metabolic rate.