Dr. Luc (Luke) van Loon

It could be genetics, but then genetics on methylation of different proteins.

And it could also be, and that's what they're now discussing, and Tim Snatters in our lab is actually doing a lot on that topic, is seeing whether the number of nuclei in the muscle...

are maintained to be increased so it's easier for the muscle to adapt to exercise.

Now there's some rodent data to suggest that.

We don't find evidence for that in human muscle.

So that you basically have more managers in your muscle fibers

that when you put a greater stress on, it's more easily managed.

But so far, we haven't seen that.

So generally, we've seen that the myonuclear content and the myonuclear domain actually nicely follows exercise training.

And it's not like it's completely different from somebody that actually did a lot of exercise 20 years ago.

Yes, likely.

Of course, you would like to get the full recovery and then the next training session.

So you optimize the reconditioning process.

And what you do notice, I mean, depends on how young you are, what training stage you are in.

I mean, I haven't seen a gym in last week, but before that in a year or two or something like that.

And then you go to a gym and then you really notice that you need actually three days before you can actually get your next session in.

When you're really in it, you actually train every day.

So it depends on your training state, your age, your genetics, what is your ideal version.

The only way to figure that one out is just try it.

There's no one rule to actually suggest that this is it.