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Dr. Majid Fotuhi

šŸ‘¤ Speaker
1224 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

So having a sense of purpose reduces the risk of dementia by 19%, reduces risk of heart attack by 12%, reduces the risk of strokes by 50%.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

In other words, you look at two groups of people

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

One group has high score for a sense of purpose in life, one group has low score.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

And then look at their brains, the people with higher sense of purpose have 50% fewer strokes than people who don't have a sense of purpose in life.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

You live longer, you have less stress, you sleep better, your brain is sharper.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

Here's another thing.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

If you look at two groups of people with the same load of plaques and tangles of Alzheimer's disease.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

So person A, let's say from one to 10, has six out of 10 plaques and tangles in their brain.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

And person B has six out of 10 plaques and tangles in their brain.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

And then you do cognitive testing on them to see how well they perform

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

on a test of cognitive functions.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

People who have a sense of purpose in life perform much better in tests of cognition than people who have low sense of purpose, even though both groups have plaques and tangles in their brain.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

There is something magical about having a sense of purpose in life.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

It has biological differences.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

And the study in Wisconsin showed that if you look at MRIs and look at the number of neurites, how many synapses they have,

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

People with a sense of purpose in life have actually more synapses.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

than people who don't.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

This is interesting because we can't have animal studies.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

We can't have like mice who have a sense of purpose in life.

Dhru Purohit Show
Alzheimer’s Isn’t Inevitable: The Science of Building a Stronger, Healthier Brain at Any Age with Dr. Majid Fotuhi

So it's hard to do hardcore scientific studies.