Dr. Martin Picard

And then that energy kind of ripples out at the level of the cell and their metabolites that are mitochondria producing.

Based on the energetic state of the mitochondria, there'll be more, you know, acetyl-CoA and citrate and lactate and alpha-ketoglutarate.

And those are all

molecular imprints of an energetic state.

And then those molecules carry this energetic signature that's in the mitochondria to the nucleus, and then boom, they get written down as the epigenome.

And now the cell all of a sudden has this gene turned down, turned off, or this other gene turned on, and now the cell is a different kind of cell.

Because there was a change at the energetic level in the mitochondria.

And then that ripples out.

Now the cell experiences its environment in a certain way energetically.

It starts in the mitochondria, ripples out to the nucleus.

Now the nucleus is able to make proteins like cytokines.

And so cytokines in many ways are signatures of an underlying energetic state.

So what we call inflammation, my understanding of inflammation is it's an energetic state.

And in many cases, if the energy doesn't flow freely or with low resistance in the system,

If you're a cell and either you're running out of oxygen, right, you're hypoxic, electrons can't flow.

As a cell, you know, you have this primal experience of what you experienced earlier, right?

You're not breathing.

You're like, I have to take a breath or I'm going to die.

So if you're a cell and you experience a version of this, a really primal version of this, you need to do something.

So you call out.