Dr. Mary-Claire King

And I would try to do that by working both with families to the extent that that's possible, but it's often not.

And to working then with our capacity to take blood cells from patients and in vitro convert those blood cells into iPSCs and then to differentiate them down

lines of various sorts of neuronal capacity so that one can see the consequences of individual damaging mutations.

Both of these ways of

approaching science, have the good feature that one can do them either in a large group or as a small project oneself.

And I think having the capacity to carry out a project where you decide what you want to do remains enormously important.

Yeah.

Yeah.

But they're not as – they're not weighty once you break them down into the component story problems.

So I think I'm both kind of denying your premise but acknowledging the reality.

Yeah.

I and the people that I work with, my posse now, we're all very hard on our evidence.

We have to be.

And the people that we ask to review our evidence are hard on it.

We don't ask people who are going to say, oh, yes, yes, dear, and pat us on the head.

No abuela has ever patted me on the head, trust me.

You need people around you who have your back vis-a-vis the outside world, but who will challenge you on your thinking as you develop the evidence.