Dr. Matthew B. (Matt) (likely the presenter) - Unknown

This is about four hours of sleep a night for four days.

It decreased insulin signaling in adipocytes by 30%.

So, I mean, your adipocytes are one of the major sinks, aside from muscle, for glucose disposal, right?

Storing it as fat for energy.

But a 30% reduction in cellular insulin signaling in adipocytes is, I mean, you're talking about, these aren't healthy people.

This is like

a healthy person immediately becoming obese or immediately becoming type 2 diabetic after just four days of sleep restriction.

So it's very profound in terms of metabolic health.

Sleep loss, mild sleep loss even, it does promote an obesogenic profile.

And so a lot of work has been done out of Eve VanCouter's lab.

And she's looked a lot at these hunger hormones, satiety hormones.

So after two days of four hours less sleep,

Leptin levels go down.

So people are not feeling satiated by their food because leptin regulates satiation And their ghrelin levels increase.

So it's a double whammy Ghrelin is the hunger hormone.

It tells you you're hungry.

And so they're getting this continual Hunger so global hunger ratings go up global appetite goes, you know up so people are not satiated by their food and they're hungry throughout their day and again

Eve VanCouter's work has shown that people eat more, and they're consuming foods and have cravings for processed foods, highly refined sugars, salty foods, processed fats and fatty foods.

So they're eating up to 45% more of those processed unhealthy foods, and their hunger ratings are 24% higher.

So they're eating even more than they would if they were getting a good night's sleep.