Dr. Matthew Hill

And so Rafi Mishulam, who was in Israel when he discovered the molecule, you know, 30 odd years ago, wanted it to reflect inner bliss. And so he named it anandamide. So it's like inner bliss with an amide bond is kind of the joke he had for it.

And so Rafi Mishulam, who was in Israel when he discovered the molecule, you know, 30 odd years ago, wanted it to reflect inner bliss. And so he named it anandamide. So it's like inner bliss with an amide bond is kind of the joke he had for it.

And so Rafi Mishulam, who was in Israel when he discovered the molecule, you know, 30 odd years ago, wanted it to reflect inner bliss. And so he named it anandamide. So it's like inner bliss with an amide bond is kind of the joke he had for it.

Ravi Mishulam was also the guy who isolated and discovered THC. So, I mean, he has a very – he's kind of the grandfather of the whole cannabinoid field. So he has a landmark paper from 1964, which ironically – and this is one of these weird pop culture things. I don't know if this is true. That paper was published on April 20th, 1964. Yeah. And so the joke is, is this where 420 came from?

Ravi Mishulam was also the guy who isolated and discovered THC. So, I mean, he has a very – he's kind of the grandfather of the whole cannabinoid field. So he has a landmark paper from 1964, which ironically – and this is one of these weird pop culture things. I don't know if this is true. That paper was published on April 20th, 1964. Yeah. And so the joke is, is this where 420 came from?

Ravi Mishulam was also the guy who isolated and discovered THC. So, I mean, he has a very – he's kind of the grandfather of the whole cannabinoid field. So he has a landmark paper from 1964, which ironically – and this is one of these weird pop culture things. I don't know if this is true. That paper was published on April 20th, 1964. Yeah. And so the joke is, is this where 420 came from?

Because the original birth date of the first THC paper was 420, 1964.

Because the original birth date of the first THC paper was 420, 1964.

Because the original birth date of the first THC paper was 420, 1964.

But yeah, so he'd been in the field for a while. And so he had studied cannabis on that side. And then in 1990, his lab isolated anandamide as being the first molecule that activated the receptor endogenously. And so it was kind of... Yeah, I think it was a little tongue-in-cheek that he named it the way he did.

But yeah, so he'd been in the field for a while. And so he had studied cannabis on that side. And then in 1990, his lab isolated anandamide as being the first molecule that activated the receptor endogenously. And so it was kind of... Yeah, I think it was a little tongue-in-cheek that he named it the way he did.

But yeah, so he'd been in the field for a while. And so he had studied cannabis on that side. And then in 1990, his lab isolated anandamide as being the first molecule that activated the receptor endogenously. And so it was kind of... Yeah, I think it was a little tongue-in-cheek that he named it the way he did.

A few years later, the second molecule, which is just called 2-arachidonylglycerol, or what we call 2-AG, that was discovered kind of in tandem, both again by Mishulin, but also by a Japanese group. And so we understand these two molecules don't do the same thing. Like, they are a bit different.

A few years later, the second molecule, which is just called 2-arachidonylglycerol, or what we call 2-AG, that was discovered kind of in tandem, both again by Mishulin, but also by a Japanese group. And so we understand these two molecules don't do the same thing. Like, they are a bit different.

A few years later, the second molecule, which is just called 2-arachidonylglycerol, or what we call 2-AG, that was discovered kind of in tandem, both again by Mishulin, but also by a Japanese group. And so we understand these two molecules don't do the same thing. Like, they are a bit different.

So the way anandamide binds to the receptor is it's what we would call a high affinity, but low efficacy agonist, or molecule at least. And what I mean by that is... Very low levels of anandamide are required to actually bind to the receptor. But once it binds, its ability to stimulate a biological response in that neuron kind of caps out pretty fast. So it doesn't have like a sledgehammer effect.

So the way anandamide binds to the receptor is it's what we would call a high affinity, but low efficacy agonist, or molecule at least. And what I mean by that is... Very low levels of anandamide are required to actually bind to the receptor. But once it binds, its ability to stimulate a biological response in that neuron kind of caps out pretty fast. So it doesn't have like a sledgehammer effect.

So the way anandamide binds to the receptor is it's what we would call a high affinity, but low efficacy agonist, or molecule at least. And what I mean by that is... Very low levels of anandamide are required to actually bind to the receptor. But once it binds, its ability to stimulate a biological response in that neuron kind of caps out pretty fast. So it doesn't have like a sledgehammer effect.

Whereas 2-AG seems to require a bit more concentration in the synapse to be able to bind to the receptor. So it has a lower affinity for the receptor. But once it binds to the receptor, it's like... pretty heavy duty. So it evokes a very robust intracellular signaling response. Why we have two endocannabinoids, we're not totally sure. Some of us have theories.

Whereas 2-AG seems to require a bit more concentration in the synapse to be able to bind to the receptor. So it has a lower affinity for the receptor. But once it binds to the receptor, it's like... pretty heavy duty. So it evokes a very robust intracellular signaling response. Why we have two endocannabinoids, we're not totally sure. Some of us have theories.