Dr. Matthew Hill

So then you go into things like dabs or these like high potency products that are now like, cause cannabis itself, realistically, From what I understand from the botanists that I've talked to, you can't really grow a plant that's gonna exceed more than 25 to 30% THC just by sheer biology. So it taps out there. That's about as high as it's gonna go. Concentrates can go up to like 90, 98%.

So you can get really, really- These are tinctures? Like, yeah, various just in oil-based forms that are very, very high-potency products. Those are incredibly challenging to titrate. Like, they cannot be titrated because the sheer volume of THC that hits the system, even from a single hit, is so overwhelming.

So you can get really, really- These are tinctures? Like, yeah, various just in oil-based forms that are very, very high-potency products. Those are incredibly challenging to titrate. Like, they cannot be titrated because the sheer volume of THC that hits the system, even from a single hit, is so overwhelming.

So you can get really, really- These are tinctures? Like, yeah, various just in oil-based forms that are very, very high-potency products. Those are incredibly challenging to titrate. Like, they cannot be titrated because the sheer volume of THC that hits the system, even from a single hit, is so overwhelming.

And so, when the Colorado group looked at those, their blood levels were closer to 200, 300 nanograms per mil. So, wow. With cannabis plant, there does seem to be this ability for people to relatively self-titrate.

And so, when the Colorado group looked at those, their blood levels were closer to 200, 300 nanograms per mil. So, wow. With cannabis plant, there does seem to be this ability for people to relatively self-titrate.

And so, when the Colorado group looked at those, their blood levels were closer to 200, 300 nanograms per mil. So, wow. With cannabis plant, there does seem to be this ability for people to relatively self-titrate.

And then my buddy Ryan McLaughlin, who's also at Washington State, he was really one of the ones that pioneered these vape chambers and rats and created this really cool model of self-administration, which was like,

And then my buddy Ryan McLaughlin, who's also at Washington State, he was really one of the ones that pioneered these vape chambers and rats and created this really cool model of self-administration, which was like,

And then my buddy Ryan McLaughlin, who's also at Washington State, he was really one of the ones that pioneered these vape chambers and rats and created this really cool model of self-administration, which was like,

A very important thing to actually establish because it was very challenging to get rodents to self-administer cannabis if you're doing like an IV approach or something else because they found it quite aversive. But when you let rodents actually tighter their ability to get vape hits, they will like work for this the same way they will other reinforcing drugs.

A very important thing to actually establish because it was very challenging to get rodents to self-administer cannabis if you're doing like an IV approach or something else because they found it quite aversive. But when you let rodents actually tighter their ability to get vape hits, they will like work for this the same way they will other reinforcing drugs.

A very important thing to actually establish because it was very challenging to get rodents to self-administer cannabis if you're doing like an IV approach or something else because they found it quite aversive. But when you let rodents actually tighter their ability to get vape hits, they will like work for this the same way they will other reinforcing drugs.

So it was a really important finding that you could do this. And what Ryan found was he actually did one study where he gave them access to a low-potency product, we'll call it medium, and then a high. And what you ended up, if you look at the data, is the one the rats liked the best was the medium-potency product. Interesting.

So it was a really important finding that you could do this. And what Ryan found was he actually did one study where he gave them access to a low-potency product, we'll call it medium, and then a high. And what you ended up, if you look at the data, is the one the rats liked the best was the medium-potency product. Interesting.

So it was a really important finding that you could do this. And what Ryan found was he actually did one study where he gave them access to a low-potency product, we'll call it medium, and then a high. And what you ended up, if you look at the data, is the one the rats liked the best was the medium-potency product. Interesting.

And if you gave them the high-potency product, they would actually take less vape hits off that than they would off the lower ones. And again, all their blood levels tended to cluster in the same range because they – Like even at the rodent level, they're able to titrate because of the lag between inhalation and feeling the effects is only on the order of a couple of minutes.

And if you gave them the high-potency product, they would actually take less vape hits off that than they would off the lower ones. And again, all their blood levels tended to cluster in the same range because they – Like even at the rodent level, they're able to titrate because of the lag between inhalation and feeling the effects is only on the order of a couple of minutes.

And if you gave them the high-potency product, they would actually take less vape hits off that than they would off the lower ones. And again, all their blood levels tended to cluster in the same range because they – Like even at the rodent level, they're able to titrate because of the lag between inhalation and feeling the effects is only on the order of a couple of minutes.

People can titrate better. I mean, not just people, it seems like the rodents can as well. So the higher potency cannabis, where it becomes a problem is if someone's highly inexperienced and they consume a whole bunch of it without allowing that time lag to occur. And then they can probably exceed the levels they intended to and consume too much and then have probably an adverse response.