Dr. Matthew Hill

One of the things with cannabis that I do find very interesting is with a lot of chronic users, they don't escalate the way you would see with cocaine or alcohol where there's very profound tolerance that develops. And so, I mean, people definitely see this in cocaine where people can become tolerant almost immediately. And so dosing starts scaling up very fast.

Seriously. Or the cost. I mean, the sheer cost.

Seriously. Or the cost. I mean, the sheer cost.

Seriously. Or the cost. I mean, the sheer cost.

Yeah, that is required to be able to maintain that. But with cannabis, it seems like there is some degree of tolerance that people exhibit. It varies from person to person. But, you know, as Meg has said to me many times, you know, the guys that come in her studies, these are very heavy users. And then, you know, they will use this relatively low potency product and still get high off of it.

Yeah, that is required to be able to maintain that. But with cannabis, it seems like there is some degree of tolerance that people exhibit. It varies from person to person. But, you know, as Meg has said to me many times, you know, the guys that come in her studies, these are very heavy users. And then, you know, they will use this relatively low potency product and still get high off of it.

Yeah, that is required to be able to maintain that. But with cannabis, it seems like there is some degree of tolerance that people exhibit. It varies from person to person. But, you know, as Meg has said to me many times, you know, the guys that come in her studies, these are very heavy users. And then, you know, they will use this relatively low potency product and still get high off of it.

And so it's not to say that there's no tolerance. It's just it's not as profound as I think we see with a lot of other drugs. And this is probably due to the fact of just like, you know, we definitely see like if we look at some pet imaging studies, chronic cannabis users do have some down.

And so it's not to say that there's no tolerance. It's just it's not as profound as I think we see with a lot of other drugs. And this is probably due to the fact of just like, you know, we definitely see like if we look at some pet imaging studies, chronic cannabis users do have some down.

And so it's not to say that there's no tolerance. It's just it's not as profound as I think we see with a lot of other drugs. And this is probably due to the fact of just like, you know, we definitely see like if we look at some pet imaging studies, chronic cannabis users do have some down.

Not good. Don't get dogs high.

Not good. Don't get dogs high.

Not good. Don't get dogs high.

Yeah, so a typical PET study in a human looking at this, they'd give a molecule that's radiolabeled that will bind to CB1 receptors. You can scan them and then look at the emission rates of the radiation to get an idea of the density of receptors that are in the brain. Chronic cannabis users tend to have less. What that means in terms of the functional outcome is unclear.

Yeah, so a typical PET study in a human looking at this, they'd give a molecule that's radiolabeled that will bind to CB1 receptors. You can scan them and then look at the emission rates of the radiation to get an idea of the density of receptors that are in the brain. Chronic cannabis users tend to have less. What that means in terms of the functional outcome is unclear.

Yeah, so a typical PET study in a human looking at this, they'd give a molecule that's radiolabeled that will bind to CB1 receptors. You can scan them and then look at the emission rates of the radiation to get an idea of the density of receptors that are in the brain. Chronic cannabis users tend to have less. What that means in terms of the functional outcome is unclear.

I mean, there could be some... I think there's a lot of evidence that there's some degree of a reservoir of CB1 receptors that, you know, there might be a lot more receptors there than we necessarily always need or are always using, let's say. So we might be down-regulating a component of this, but maybe not all of the ones that are required to produce the psychoactive effects.

I mean, there could be some... I think there's a lot of evidence that there's some degree of a reservoir of CB1 receptors that, you know, there might be a lot more receptors there than we necessarily always need or are always using, let's say. So we might be down-regulating a component of this, but maybe not all of the ones that are required to produce the psychoactive effects.

I mean, there could be some... I think there's a lot of evidence that there's some degree of a reservoir of CB1 receptors that, you know, there might be a lot more receptors there than we necessarily always need or are always using, let's say. So we might be down-regulating a component of this, but maybe not all of the ones that are required to produce the psychoactive effects.

There's clearly some maintenance of the system that allows someone to continue to get intoxicated. And so with cannabis users, we do see that. But you do see much more profound tolerance with people using high potency extracts and concentrates and things like this.